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Table 3 KEGG pathways associated to Pax8 silencing

From: Genome-wide analysis of Pax8 binding provides new insights into thyroid functions

Global class

 

KEGG pathway

Scr. vs Pax8

adjp-value

Wt. vs Pax8

adjp-value

Downreg. probes

Phosph. I.

Phosphatidylinositol signaling system

1.28E-03

8.10E-05

 

Inositol phosphate metab.

4.18E-02

9.88E-04

Aa metab.

Glycine, serine and threonine metab.

1.25E-04

2.42E-02

 

Selenoamino acid metab.

1.61E-03

1.16E-02

 

Cysteine and methionine metab.

7.21E-03

1.25E-03

 

Arginine and proline metab.

1.06E-02

9.73E-07

Cell cycle

Cell cycle

9.67E-05

9.73E-07

CAMs

Cell adhesion molecules

9.37E-03

5.39E-03

Immune response

Antigen processing and presentation

1.56E-05

2.86E-03

 

Autoimmune thyroid disease

5.26E-04

2.76E-03

DNA/RNA processes

Purine metab.

1.56E-05

9.52E-09

 

Base excision repair

5.85E-05

2.20E-03

 

Pyrimidine metab.

1.25E-04

5.86E-09

 

Nucleotide excision repair

2.99E-04

3.22E-03

 

RNA degradation

9.95E-04

2.76E-03

 

Mismatch repair

1.22E-03

4.76E-05

 

Homologous recombination

2.30E-02

7.50E-03

 

DNA replication

2.88E-02

2.98E-06

Signaling pathways

p53 signaling pathway

7.24E-03

7.26E-07

Upreg. probes

Cell processes

Endocytosis

1.13E-10

4.66E-14

 

Lysosome

1.23E-06

1.55E-05

Cell migration/adhesion

Cell adhesion molecules

2.43E-09

1.59E-06

Signaling pathways

Cytosolic DNA- sensing pathway

4.36E-04

5.70E-06

 

NOD-like receptor signaling pathway

2.59E-03

9.17E-05

 

Toll-like receptor signaling pathway

4.26E-06

3.52E-07

 

Chemokine signaling pathway

1.91E-05

9.22E-06

 

MAPK signaling

7.52E-06

4.69E-07

Cancer

Thyroid cancer

1.65E-02

1.23E-04

 

Prostate cancer

2.30E-05

4.74E-07

 

Endometrial cancer

8.49E-04

1.49E-05

 

Pancreatic cancer

1.34E-05

7.79E-06

 

Renal cell carcinoma

1.95E-03

9.22E-06

 

Colorectal cancer

1.16E-03

4.71E-05

 

Pathways in cancer

5.20E-06

2.07E-10

Immune response

Viral myocarditis

2.49E-11

2.68E-08

 

Graft-versus-host disease

1.53E-09

5.16E-07

 

Allograft rejection

9.99E-08

4.28E-06

 

Autoimmune thyroid disease

2.53E-08

1.59E-06

  

Antigen processing and presentation

1.13E-10

5.06E-13

  1. Most significant KEGG pathways enriched among common downregulated (n = 633) and upregulated (n = 565) probes for both expression array comparisons. Downreg.: Downregulated; Upreg.: Upregulated; adj p-value: adjusted p-value; Phosph.I:Phosphatidylinositol; Aa: Amino acid; metab.:metabolism.