From: Genome-wide analysis of Pax8 binding provides new insights into thyroid functions
Global class | KEGG pathway | Scr. vs Pax8 adjp-value | Wt. vs Pax8 adjp-value | |
---|---|---|---|---|
Downreg. probes | Phosph. I. | Phosphatidylinositol signaling system | 1.28E-03 | 8.10E-05 |
Inositol phosphate metab. | 4.18E-02 | 9.88E-04 | ||
Aa metab. | Glycine, serine and threonine metab. | 1.25E-04 | 2.42E-02 | |
Selenoamino acid metab. | 1.61E-03 | 1.16E-02 | ||
Cysteine and methionine metab. | 7.21E-03 | 1.25E-03 | ||
Arginine and proline metab. | 1.06E-02 | 9.73E-07 | ||
Cell cycle | Cell cycle | 9.67E-05 | 9.73E-07 | |
CAMs | Cell adhesion molecules | 9.37E-03 | 5.39E-03 | |
Immune response | Antigen processing and presentation | 1.56E-05 | 2.86E-03 | |
Autoimmune thyroid disease | 5.26E-04 | 2.76E-03 | ||
DNA/RNA processes | Purine metab. | 1.56E-05 | 9.52E-09 | |
Base excision repair | 5.85E-05 | 2.20E-03 | ||
Pyrimidine metab. | 1.25E-04 | 5.86E-09 | ||
Nucleotide excision repair | 2.99E-04 | 3.22E-03 | ||
RNA degradation | 9.95E-04 | 2.76E-03 | ||
Mismatch repair | 1.22E-03 | 4.76E-05 | ||
Homologous recombination | 2.30E-02 | 7.50E-03 | ||
DNA replication | 2.88E-02 | 2.98E-06 | ||
Signaling pathways | p53 signaling pathway | 7.24E-03 | 7.26E-07 | |
Upreg. probes | Cell processes | Endocytosis | 1.13E-10 | 4.66E-14 |
Lysosome | 1.23E-06 | 1.55E-05 | ||
Cell migration/adhesion | Cell adhesion molecules | 2.43E-09 | 1.59E-06 | |
Signaling pathways | Cytosolic DNA- sensing pathway | 4.36E-04 | 5.70E-06 | |
NOD-like receptor signaling pathway | 2.59E-03 | 9.17E-05 | ||
Toll-like receptor signaling pathway | 4.26E-06 | 3.52E-07 | ||
Chemokine signaling pathway | 1.91E-05 | 9.22E-06 | ||
MAPK signaling | 7.52E-06 | 4.69E-07 | ||
Cancer | Thyroid cancer | 1.65E-02 | 1.23E-04 | |
Prostate cancer | 2.30E-05 | 4.74E-07 | ||
Endometrial cancer | 8.49E-04 | 1.49E-05 | ||
Pancreatic cancer | 1.34E-05 | 7.79E-06 | ||
Renal cell carcinoma | 1.95E-03 | 9.22E-06 | ||
Colorectal cancer | 1.16E-03 | 4.71E-05 | ||
Pathways in cancer | 5.20E-06 | 2.07E-10 | ||
Immune response | Viral myocarditis | 2.49E-11 | 2.68E-08 | |
Graft-versus-host disease | 1.53E-09 | 5.16E-07 | ||
Allograft rejection | 9.99E-08 | 4.28E-06 | ||
Autoimmune thyroid disease | 2.53E-08 | 1.59E-06 | ||
Antigen processing and presentation | 1.13E-10 | 5.06E-13 |