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Table 4 The downward effect of JTX on the gene expression in the small intestine in IQI GF mice

From: Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-α response via affecting the ISGF3-IRF7 signaling cascade

GFSI-down

    

Probe Set ID

Gene Name

Gene Symbol

Entre ID

Fold Change

p-value

103842_at

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

Ddx3y

26900

0.01

0.006

103674_f_at

eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked

Eif2s3y

26908

0.03

0.022

95024_at

ubiquitin specific peptidase 18

Usp18

24110

0.11

0.003

100981_at

interferon-induced protein with tetratricopeptide repeats 1

Ifit1

15957

0.15

0.010

93956_at

interferon-induced protein with tetratricopeptide repeats 3

Ifit3

15959

0.17

0.009

160933_at

interferon gamma induced GTPase

Igtp

16145

0.19

0.000

98822_at

ISG15 ubiquitin-like modifier

G1p2

53606

0.20

0.035

92718_at

interferon, alpha-inducible protein 27

Ifi27

76933

0.24

0.019

104750_at

interferon gamma inducible protein 47

Ifi47

15953

0.25

0.009

98030_at

tripartite motif protein 30

Trim30

20128

0.25

0.003

104177_at

radical S-adenosyl methionine domain containing 2

Rsad2

58185

0.27

0.004

102906_at

T-cell specific GTPase

Tgtp

21822

0.29

0.000

92472_f_at

schlafen 2

Slfn2

20556

0.31

0.004

98410_at

interferon inducible GTPase 2

Iigp2

54396

0.32

0.007

103066_at

thymidylate kinase family LPS-inducible member

Tyki

22169

0.36

0.024

97409_at

immunity-related GTPase family, M

Irgm

15944

0.36

0.021

103446_at

interferon induced with helicase C domain 1

Ifih1

71586

0.39

0.010

102699_at

myxovirus (influenza virus) resistance 2

Mx2

17858

0.42

0.012

93078_at

lymphocyte antigen 6 complex, locus A

Ly6a

110454

0.43

0.030

160668_at

opioid growth factor receptor

Ogfr

72075

0.44

0.006

103254_at

TRAF type zinc finger domain containing 1

Trafd1

231712

0.44

0.043

103202_at

guanylate nucleotide binding protein 4

Gbp4

55932

0.44

0.013

101465_at

signal transducer and activator of transcription 1

Stat1

20846

0.44

0.021

103634_at

interferon dependent positive acting transcription factor 3 gamma

Isgf3g

16391

0.47

0.006

103035_at

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Tap1

21354

0.48

0.027

103080_at

SAM domain and HD domain, 1

Samhd1

56045

0.50

0.016

103812_at

chloride channel calcium activated 1

Clca1

12722

0.50

0.019

160847_at

tRNA nucleotidyl transferase, CCA-adding, 1

Trnt1

70047

0.52

0.014

102873_at

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Tap2

21355

0.57

0.037

100475_at

tripartite motif protein 25

Trim25

217069

0.58

0.025

98283_at

5'-3' exoribonuclease 1

Xrn1

24127

0.61

0.005

96151_at

Molybdenum cofactor sulfurase

Mocos

68591

0.61

0.010

102812_i_at

ubiquitin-activating enzyme E1-domain containing 1

Ube1dc1

66663

0.62

0.003

94461_at

pre-B-cell colony-enhancing factor 1

Pbef1

59027

0.62

0.030

95886_g_at

CREB binding protein

Crebbp

12914

0.63

0.012

103673_at

complement component 2 (within H-2S)

C2

12263

0.63

0.013

97921_at

Agrin

Agrn

11603

0.63

0.043

102279_at

ubiquitin-activating enzyme E1-like

Ube1l

74153

0.64

0.013

104070_at

p300/CBP-associated factor

Pcaf

18519

0.64

0.002

96157_at

zinc finger protein 91

Zfp91

109910

0.65

0.009

94192_at

ganglioside-induced differentiation-associated-protein 10

Gdap10

14546

0.66

0.049

103025_at

Moloney leukemia virus 10

Mov10

17454

0.67

0.042

  1. The genes whose change was < 0.67 fold and with p < 0.1 (n = 3, Welch's t test) were the listed sorted by fold-change. Eight immunoglobulin genes and 14 unidentified probe sets were omitted from the lists. The genes appeared commonly in both Tables 3 and 4 were in bold letters. The genes appeared commonly in Tables 1 and 4 were underlined.
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BMC Genomics

ISSN: 1471-2164

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