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Table 6 Putative promoter modules affected by JTX treatment

From: Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-α response via affecting the ISGF3-IRF7 signaling cascade

module

# module matches (# sequences)

Appearance ratio (# matches/# sequences)

Significance

 

SPFLI-up (26)

BALB -down (26)

GFLI -down (45)

GFSI down (55)

All promoters (51460)

SPFLI-up/BALB-down/GFLI-down/GFSI-down*

All annotated promoters

 

V$IRFF-V$IRFF

31

33

55

67

19374

1.225 ± 0.032

0.376

< 0.0001

V$IRFF-V$MYT1

14

12

24

30

13423

0.520 ± 0.039

0.261

0.0009

V$CREB-V$GCMF

4

6

10

14

4675

0.215 ± 0.043

0.091

0.0104

V$ETSF-V$DEAF

3

8

17

17

6540

0.277 ± 0.113

0.127

0.0706

  1. * The values represent the mean ± S.D. of the appearance ration of these 4 groups.
  2. Definition of promoter modules**
  3. V$IRFF: interferon regulatory fatctors,
  4. V$MYT1: MYT1 C2HC zinc finger protein,
  5. V$CREB: cAMP-responsive element binding proteins,
  6. V$GCMF: Chorion-specific transcription factors with a GCM DNA binding domain,
  7. V$ETSF: Ets1 factors,
  8. V$DEAF: Homolog to deformed epidermal autoregulatory factor-1 from D. melanogaster
  9. **See Website of Genomatix Inc http://www.genomatix.de/ for further information.