Discovery and validation of gene classifiers for endocrine-disrupting chemicals in zebrafish (danio rerio)

BMC Genomics

Table 4 Number of gene features in qualified classifiers for various chemical-tissue conditions

Chemical	No. unique gene features (total)
Chemical	Brain	Ovary	Testis	Subtotal by chemical
Prochloraz	1236 (3391)	277 (1437)	335 (1550)	1848 (6378)
Flutamide	NA	814 (2491)	0	814 (2491)
17α-ethynyl estradiol	221 (897)	---	252 (737)	473 (1634)
Fipronil	261 (1370)	47 (338)	53 (353)	361 (2061)
Vinclozolin	NA	131 (662)	3 (6)	134 (668)
Ketoconazole	84 (519)	30 (185)	---	114 (704)
Fadrozole	14 (115)	0	NA	14 (115)
Muscimol	78 (656)	---	NA	78 (656)
17β-trenbolone	---	0	NA
Trilostane	NA	---	0
Subtotal by tissue	1894	1299	643

Based on Agilent probe IDs, each total count includes those gene features overlapping among multiple classifiers. While search was network-specific, gene features were summarized across multiple networks in a classifier for a given condition where available. A total of 7522 features were selected into classifiers for the 15 conditions listed. “NA”, not included in the study; “---“, insufficient sample size for classifier search; “0”, searched but no qualified classifier.

ISSN: 1471-2164