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Figure 3 | BMC Genomics

Figure 3

From: The ribonuclease Dis3 is an essential regulator of the developmental transcriptome

Figure 3

Transcriptomic analysis of Dis3 knock down flies. (a) Experimental design; black bar indicates the RNA collection time for specific development time periods. (b) Heatmap shows the genome-wide RNA expression profile. Rows correspond to the wild-type (w1118) and Dis3-depleted (Dis3KD) development stages; columns correspond to 11,665 annotated Drosophila genes. The color key represents log2 transformed RPKM value. Red indicates high expression; blue indicates low expression. Expression profiles are clustered using hierarchical clustering. (c) Number of RNAs with 2x fold change and 5x fold change in Dis3KD flies in 6 development time points as compared to wild type files. (d) Dis3 relative expression level in wild type and Dis3KD flies in 6 development time points. (e) Relative Dis3 expression level in wild type and Dis3KD flies in 6 development time points measured by qRT-PCR.

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