Figure 5

Differences in H3K4me3 signal in cell-type specific peak regions suggest cell-type specific regulation. H3K4me3 enrichment for the two cell types in peak regions that are cell-type specific for K562 (A) and HeLa-S3 (B) and in peak regions that are common for both cell types (A and B). Only the 30% highest peaks are analyzed. A) Box-plots showing for K562-specific TF peak regions, the distributions of H3K4me3 ChIP-seq signal in K562 (red) and HeLa-S3 (green), and for TF peak regions common to K562 and HeLa-S3, the distribution of H3K4me3 ChIP-seq signal in K562 (blue). The H3K4me3 ChIP-seq signal was the read per million-normalized number of reads mapping to each peak region divided by the region length. BRF2 has only one box-plot as all BRF2 peaks overlapped in the two cell lines. B) Similar data as in (A), but for HeLa-S3-specific peak regions the H3K4me3 ChIP-seq signal in HeLa-S3 (green) and K562 (red) and for peak regions common to K562 and HeLa-S3 the H3K4me3 ChIP-seq signal in HeLa-S3 (blue). The H3K4me3 ChIP-seq data show the same patterns as the DNase-seq data (see Figure4).