Figure 7

Interactions are observed between several QTLs. The graph displays pair-scan results for the trait percent survival at day 8 p.i. (ID13002) (A). The upper left half of the plot highlights any epistatic interactions, the lower right half provides a summary of LRS of the full model, representing cumulative effects of linear and non-linear terms based on the model ‘Trait Variance = Q1 + Q2 + Q1 x Q2 ’. Subsequently, BXD lines were grouped according to their allele combinations and trait values were compared between groups (B, C). The largest differences are indicated by asterisks. They are highly significant between the respective groups (p < 0.0001). For the various loci, trait values for the following markers were used: Qivr5: rs13478587, chromosome 9: rs6191976, Qivr19: rs13483633. Number of lines and p-values for Qivr5 – chromosome 9: D2/D2: n = 17, D2/B6: n = 17, B6/D2: n = 6, B6/B6 n = 12; D2/D2 vs B6/B6: p < 0.0001, D2/B6 vs B6/B6: p = 0.003. Number of lines and p-values for Qivr5 – Qivr19: D2/D2: n = 18, D2/B6: n = 16, B6/D2: n = 4, B6/B6: n = 14; p-values: D2/D2 vs B6/B6: p < 0.0001, D2/B6 vs B6/B6: p = 0.0008. Abbreviations: D2: DBA/2J, B6: C57BL/6J.