Figure 11

OR genes are enriched with non-synonymous SNPs. Each panel compares the frequency distribution (f) for ORs (orange) and control genes (green). The analysis is done using three data sources: 1000 Genomes Project (A, B) with 581 genes with a single coding exon as controls; the GeneCards database [50] (C, D), with 15,425 protein coding genes as controls; all 10 data sources (Additional file 1: Table S1) (E, F), with OR pseudogenes as controls. A, C, E, non-synonymous SNPs, B, D, F, synonymous SNPs.