Figure 1
From: An evaluation of two-channel ChIP-on-chip and DNA methylation microarray normalization strategies
The birth of an enrichment signal around a binding site (ChIP-on-chip). Since DNA fragmentation through sonication can be modeled as a Poisson process [1], the DNA fragment length distribution follows a Poisson distribution and adjacent probes on the genome have a correlated log-ratio, resulting in the hybridization pattern shown here. Each blue column represents a probe hybridization site. Black-outlined bars represent their log-ratio. Green lines are sonicated immuno-precipitated DNA fragments corresponding to the binding site.