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Table 3 Shared effects of fasting and insulin-neutralization on differential gene expression

From: Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting

Gene symbol

Gene title

Fold change Insu-Neu vs. Fed

Fold change Fasting vs. Fed

Up-regulated genes

PDK4

pyruvate dehydrogenase kinase, isozyme 4

7.06

17.28

AOX1

aldehyde oxidase 1

2.94

6.66

PLEKHH2

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

2.41

2.77

FBXO8

F-box protein 8

2.09

4.15

AGTR1

angiotensin II receptor, type 1

2.04

4.15

PCMTD1

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1

1.99

2.25

PSME4

proteasome (prosome, macropain) activator subunit 4

1.97

3.86

ICA1

islet cell autoantigen 1, 69 kDa

1.85

2.8

IP6K2

inositol hexakisphosphate kinase 2

1.77

2.75

UHRF2

ubiquitin-like, containing PHD and RING finger domains, 2

1.72

1.89

ACBD5

acyl-Coenzyme A binding domain containing 5

1.72

2.51

LOC417776

similar to hypothetical protein

1.62

1.84

CTSL2

cathepsin L2

1.54

2.09

ZNF217

zinc finger protein 217

1.54

2.6

IFNAR1

Interferon (alpha, beta and omega) receptor 1

1.52

3.47

Down-regulated genes

DGAT2

diacylglycerol O-acyltransferase homolog 2 (mouse)

6.1

10.5

EEPD1

endonuclease/exonuclease/phosphatase family domain containing 1

2.4

2.17

ANKRD9

ankyrin repeat domain 9

2.19

1.98

DLST

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex

1.95

1.76

PTP4A3

protein tyrosine phosphatase type IVA, member 3

1.8

2.3

HSPA5

heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)

1.76

1.74

NOLA2

nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)

1.73

1.57

MST1R

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

1.71

2.2

GRAMD2

GRAM domain containing 2

1.69

2.37

DHDDS

dehydrodolichyl diphosphate synthase

1.63

1.58

DYNLL2

dynein, light chain, LC8-type 2

1.6

2.52

CDT1

chromatin licensing and DNA replication factor 1

1.57

1.51

FAHD1

fumarylacetoacetate hydrolase domain containing 1

1.56

1.61

DOT1L

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

1.56

1.82

BTBD11

BTB (POZ) domain containing 11

1.55

1.71

  1. FDR p-value <0.05.
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BMC Genomics

ISSN: 1471-2164

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