Table 1 Intestine transcripts corresponding to the top 100 most significant features exhibiting differential expression between diets
Accession no | Gene | VO/FO | p- value | |
|---|---|---|---|---|
| Â | Â | Lean | Fat | Â |
Metabolism (39%) | ||||
Lipid metabolism (9%) | ||||
DW590668 | Fatty aldehyde dehydrogenase | - 1.1 | - 1.2 | 0.0003 |
CK888998 | Ethanolamine kinase 1 | 1.2 | 1.2 | 0.0008 |
CK884623 | Epidermis-type arachidonate lipoxygenase 3 | 1.4 | 1.1 | 0.0010 |
CK885725 | Protein containing a beta-ketoacyl synthase domain | 1.4 | 1.6 | 0.0017 |
AF478472 | Delta-5 fatty acyl desaturase | 1.2 | 2.5 | 0.0019 |
Energy metabolism/generation of precursor metabolites (11%) | ||||
CK885194 | Cytochrome c oxidase subunit 5A | - 1.2 | - 1.1 | 0.0000 |
bra_snb_03E12 | NADH dehydrogenase subunit 1 | - 1.3 | - 1.2 | 0.0000 |
EG649067 | Ubiquinol-cytochrome c reductase core protein 1 | - 1.2 | - 1.1 | 0.0004 |
CK884638 | Uncoupling protein | - 1.3 | −1.3 | 0.0019 |
CK890974 | Mitochondrial calcium-dependent solute carrier SCaMC-2 | - 1.5 | 1.0 | 0.0021 |
EG648806 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 9 | - 1.1 | - 1.1 | 0.0022 |
Protein and amino acid metabolism (9%) | ||||
CK877521 | Kunitz-type protease inhibitor 2 precursor | 1.2 | 1.1 | 0.0002 |
DW590246 | Betaine aldehyde dehydrogenase | - 1.4 | - 1.0 | 0.0005 |
CK885180 | Fumarylacetoacetate hydrolase domain-containing protein 2B | - 1.4 | - 1.3 | 0.0007 |
CK897653 | Ubiquitin-conjugating enzyme E2 A | 1.2 | 1.2 | 0.0012 |
CK885145 | Lysosomal protective protein precursor (Cathepsin A) | 1.1 | 1.1 | 0.0014 |
Carbohydrate metabolism (5%) | ||||
EG649263 | Endosulfine alpha | - 1.3 | - 1.0 | 0.0005 |
CK885545 | Glucose transporter type 8 | 1.0 | 1.5 | 0.0013 |
Xenobiotic and oxidant metabolism (5%) | ||||
CK885392 | Catalase | 1.6 | 1.1 | 0.0000 |
CO472279 | Cytochrome P450 1a | 1.2 | 1.4 | 0.0004 |
CK898307 | Selenoprotein H-like protein | 1.3 | 1.1 | 0.0013 |
Transport/ intracellular trafficking (5%) | ||||
EG647578 | Calcium-activated potassium channel subunit alpha 1 | 1.3 | 1.2 | 0.0005 |
EG648841 | Sodium-coupled neutral amino acid transporter 2 | - 1.2 | - 1.2 | 0.0007 |
EG648303 | Mitochondrial import receptor subunit TOM20 homolog | - 1.1 | - 1.1 | 0.0011 |
Regulation of transcription (13%) | ||||
CK898304 | C-Maf | 1.6 | 1.6 | 0.0000 |
CK890154 | Butyrate response factor 2 | 1.6 | 1.2 | 0.0001 |
EG647831 | Proliferation-associated 2G4 b | - 1.3 | - 1.2 | 0.0003 |
AM041851 | Enhancer trap locus homolog 1 | - 1.1 | - 1.2 | 0.0004 |
CK885179 | Steroid receptor RNA activator 1 | - 1.3 | - 1.3 | 0.0007 |
CK884728 | Butyrate response factor 1 | 1.1 | 1.4 | 0.0011 |
CK879187 | Enhancer of polycomb homolog 1 | 1.4 | 1.1 | 0.0020 |
Translation (17%) | ||||
CK878380 | 40S ribosomal protein S18 | - 1.1 | - 1.2 | 0.0003 |
DW591873 | 60S acidic ribosomal protein | - 1.3 | - 1.2 | 0.0006 |
EG648644 | 60S ribosomal protein L29 | - 1.1 | - 1.2 | 0.0011 |
DW590580 | 40S ribosomal protein S5 | - 1.2 | - 1.2 | 0.0011 |
CK880046 | 40S ribosomal protein S28 | - 1.1 | - 1.2 | 0.0017 |
EG649167 | 60S ribosomal protein L37a | - 1.1 | - 1.2 | 0.0017 |
EG648512 | 60S ribosomal protein L41 | - 1.1 | - 1.2 | 0.0017 |
CK886042 | 60S ribosomal protein L31 | - 1.1 | - 1.3 | 0.0021 |
CK895350 | 60S ribosomal protein L36 | - 1.1 | - 1.1 | 0.0021 |
Signalling/Signal transduction (17%) | ||||
CK874863 | Proto-oncogene serine/threonine-protein kinase | 1.1 | 1.1 | 0.0002 |
CK881266 | Mitogen-activated protein kinase kinase kinase kinase 1 | 1.2 | 1.2 | 0.0002 |
CK878590 | Serine/threonine protein kinase (Tribbles homolog 2) | - 1.1 | - 1.3 | 0.0004 |
AJ425351 | Tensin-like C1 domain-containing | - 2.0 | - 1.2 | 0.0006 |
CK885079 | Sonic hedgehog-like protein | 1.3 | 1.0 | 0.0008 |
CN181161 | TGF-beta type II receptor | 1.1 | 1.1 | 0.0009 |
EG649257 | Serine/threonine-protein kinase VRK3 | - 1.1 | - 1.2 | 0.0009 |
CK886267 | Guanylate cyclase 2C | 1.1 | 1.1 | 0.0011 |
CK884467 | Serine/threonine-protein phosphatase 2A regulatory subunit B | - 1.4 | - 1.3 | 0.0020 |
Structural proteins (7%) | ||||
mus_snm_13F09 | Myosin heavy chain | - 1.2 | - 1.1 | 0.0002 |
CK885118 | Cardiac tropomyosin | 1.0 | 1.1 | 0.0013 |
CK883354 | Troponin C | 1.2 | 1.2 | 0.0017 |
EG647866 | Tubulin alpha chain | - 1.2 | - 1.2 | 0.0020 |
Immune response (2%) | ||||
BM414177 | Liver-expressed antimicrobial peptide 2 | 1.5 | 1.4 | 0.0022 |
Miscellaneous | ||||
CK884634 | Ezrin-radixin-moesin binding phosphoprotein 50 | 1.1 | 1.1 | 0.0003 |
EG648821 | Transposase | - 1.1 | - 1.2 | 0.0004 |
CK883634 | Poly [ADP-ribose] polymerase 12 | 1.3 | 1.1 | 0.0006 |
CK885090 | Claudin 15 | 1.2 | 1.1 | 0.0008 |
DW589291 | Transposase | - 1.3 | - 1.3 | 0.0009 |
CK878888 | Splicing factor, arginine/serine-rich 3 | - 1.3 | - 1.2 | 0.0013 |
CK885098 | RNA-binding protein with multiple splicing 2 | - 1.4 | - 1.2 | 0.0013 |
CK891747 | Occludin | - 1.2 | - 1.2 | 0.0014 |
CK888908 | All-trans-retinol 13,14-reductase precursor | 1.1 | 1.2 | 0.0017 |
CK880622 | Cyclin G1 | - 1.1 | - 1.2 | 0.0019 |
CK885604 | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | - 1.6 | - 1.3 | 0.0020 |
CK891699 | Barrier-to-autointegration factor | - 1.1 | - 1.2 | 0.0020 |
CK879123 | Hemoglobin subunit beta | 1.5 | 1.0 | 0.0022 |