Table 3 Top 20 KEGG pathways based on gene number following TNF α treatment
KEGG canonical pathway name | Gene number | Over-represent fold | q Value |
|---|---|---|---|
Metabolic pathways | 39 | 2.125783 | 9.13E-05 |
Pathways in cancer | 35 | 6.322678 | 5.29E-16 |
Cytokine-cytokine receptor interaction | 33 | 7.502728 | 5.05E-17 |
Cell adhesion molecules (CAMs) | 22 | 9.817002 | 4.87E-14 |
Chemokine signaling pathway | 22 | 6.851449 | 5.71E-11 |
Focal adhesion | 21 | 6.216256 | 8.39E-10 |
MAPK signaling pathway | 20 | 4.412876 | 5.87E-07 |
Tight junction | 17 | 7.585865 | 2.33E-09 |
Small cell lung cancer | 16 | 11.12455 | 4.05E-11 |
Toll-like receptor signaling pathway | 16 | 9.472391 | 3.54E-10 |
Regulation of actin cytoskeleton | 15 | 4.152394 | 3.88E-05 |
Axon guidance | 14 | 6.489322 | 5.87E-07 |
Leukocyte transendothelial migration | 13 | 6.532169 | 1.44E-06 |
Epithelial cell signaling in Helicobacter pylori infection | 12 | 10.55196 | 2.34E-08 |
Neurotrophin signaling pathway | 12 | 5.649871 | 1.69E-05 |
Hematopoietic cell lineage | 11 | 7.474308 | 3.16E-06 |
Natural killer cell mediated cytotoxicity | 11 | 4.801016 | 0.000148 |
Endocytosis | 11 | 3.517322 | 0.001595 |
ECM-receptor interaction | 10 | 7.118389 | 1.62E-05 |
Antigen processing and presentation | 10 | 6.718479 | 2.42E-05 |