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Table 4 Disease-associated chromosomal regions containing PML target genes

From: Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFα) signaling in endothelial cells

Chromosome region

Related health conditions and references

Genes in region and fold change

  

Symbol

siP1-siC

siP2-siC

  

ACSL3

0.59

0.44

  

DOCK10

0.48

0.53

  

C2orf33

0.47

0.58

 

2q37 deletion syndrome (intellectual disability, autism, short

SLC16A14

0.63

0.64

2q36.3–37.1

stature, obesity, and characteristic facial features) (Casas et al.

CAB39

0.42

0.58

 

2004)

ITM2C

0.23

0.34

  

HTR2B

0.65

0.58

  

ATG16L1

0.63

0.57

  

MAPK13

0.55

0.50

  

TAPBP

0.26

0.50

  

NOTCH4

0.21

0.22

  

CFB

0.59

0.55

  

HSPA1B

0.66

0.48

  

HLA-B

0.27

0.16

 

leukemia, lymphoma, other cancers, multiple sclerosis, chronic

HLA-C

0.59

0.45

 

inflammatory arthritis, type I diabetes, psoriasis, other

LTB

0.65

0.65

6p21.3–22.2

autoimmue diseases. (Sawcer et al 1996, Bevan et al 2000,

HCP5

0.34

0.26

 

Concannon et al 2005, Maleno et al 2005, Qiao et al 2007,

HLA-A

0.15

0.21

 

Slager et al 2011, Conde et al 2010)

HLA-G

0.60

0.65

  

PRR3

0.66

0.61

  

HLA-F

0.64

0.54

  

ZNF193

0.56

0.65

  

HIST1H4K

0.36

0.23

  

HIST1H2BD

0.45

0.44

  

TRIM38

0.65

0.61

  

TMEM106C

2.06

1.94

  

FKBP11

2.44

2.06

  

TROAP

2.50

1.55

  

KRT7

5.10

3.58

  

MFSD5

2.09

1.92

  

TARBP2

1.67

1.76

  

ATP5G2

2.11

1.53

12q13–14

Intimal sarcoma, lymphoma, gliomas. (Reifenberger et al 1994,

BLOC1S1

2.12

1.95

 

Rao et al 1998, Bode-Lesniewska et al 2001)

CDK2

4.87

3.73

  

FAM62A

1.65

1.69

  

STAT6

1.63

1.58

  

SHMT2

1.78

1.88

  

CDK4

2.02

2.29

  

CTDSP2

2.37

2.21

  

FAM119B

2.79

2.82

  

MSRB3

3.36

4.34

  

RPLP0

1.92

2.05

  

MLEC

2.19

1.84

 

Teratocarcinoma, dysmorphic features and developmental

DENR

2.14

2.93

 

delay, beckwith-wiedemann syndrome, mitochondrial

FAM101A

1.77

2.08

12q24.31–33

myopathy, asthma. (Deyo et al 1998 , Casas et al 2004,

ZNF664

2.84

3.49

 

Brasch-Andersen et al 2006, Baple et al 2010, Al-Zahrani et al

STX2

3.77

3.51

 

2011)

POLE

3.74

2.56

  

PXMP2

1.79

1.67

  

PLAGL2

1.82

1.70

  

TPX2

4.68

3.11

20q11.21–23

Bladder cancer, type II diabetes,myocardial infarction.

C20orf127

2.07

2.10

 

(Tanahashi et al 2006, Potter et al 2008, Sherva et al 2008)

BLCAP

2.07

1.67

  

TGM2

7.82

7.35

  

C20orf129

4.15

2.82

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BMC Genomics

ISSN: 1471-2164

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