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Table 5 The miRNAs significantly up or down regulated in the necrotic tissue, ordered by the fold change (FC)

From: Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae

Annotation

Annotation coordinates

Normalized read counts

log2(FC)

p-value

Necrotic

Unaffected

miR-223(Q)

chrX:51247504–51247526:-

10,712.16

367.80

−4.86

2.38E-10

miR-d12

chr17:37143883–37144004:+

28.35

1.80

−3.97

2.65E-05

mir-451(Q)

chr12:42820765–42820830:-

49,029.44

3,944.06

−3.64

5.16E-07

mir-582

chr16:36589520–36589618:+

193.02

25.64

−2.91

6.40E-05

mir-7

chr1:200316408–200316468:-

708.65

111.38

−2.67

1.37E-04

mir-144(Q)

chr12:42820909–42820993:-

8,968.19

1,426.54

−2.65

1.34E-04

mir-146a(Q)

chr16:60604389–60604467:+

3,486.58

635.24

−2.46

3.68E-04

mir-15b

chr13:78787510–78787608:+

1,150.04

278.66

−2.05

2.70E-03

mir-19a

chr11:60972740–60972822:+

114.73

28.65

−2.00

5.07E-03

mir-142(Q)

chr12:32630402–32630482:-

11,700.22

2,961.25

−1.98

3.43E-03

miR-d1

chr2:6684268–6684379:-

31.05

8.21

−1.92

1.83E-02

mir-132

chr12:45599471–45599572:-

82.34

25.04

−1.72

1.70E-02

mir-222

chrX:40478833–40478913:-

134.98

42.87

−1.65

1.77E-02

mir-221

chrX:40478093–40478163:-

827.44

271.44

−1.61

1.71E-02

miR-d5(Q)

chr5:4391269–4391380:-

10,960.52

3,887.77

−1.50

2.51E-02

mir-505

chrX:112590811–112590891:+

62.09

22.04

−1.49

3.84E-02

mir-128-1

chr15:14550873–14550955:-

107.99

40.47

−1.42

4.40E-02

mir-542

chrX:108481538–108481618:-

715.40

1,961.41

1.46

2.97E-02

mir-10a

chr12:22389423–22389503:-

8,433.66

26,108.75

1.63

1.50E-02

mir-30c-2

chr1:53819905–53819985:-

80.99

257.42

1.67

1.63E-02

mir-181a-1

chr10:22839351–22839455:-

37.79

122.60

1.70

1.90E-02

mir-138a

chr13:23336889–23336951:+

82.34

272.45

1.73

1.31E-02

mir-497

chr12:49575593–49575673:+

51.29

181.10

1.82

1.03E-02

mir-126(Q)

chr1:294113068–294113141:+

15,131.46

54,694.16

1.85

5.98E-03

mir-450b

chrX:108480528–108480608:-

66.14

248.61

1.91

6.66E-03

mir-100

chr9:47702720–47702800:-

527.78

2,599.26

2.30

8.24E-04

mir-181b-2

chr1:280335867–280335953:+

2.70

17.03

2.66

2.02E-02

mir-450a

chrX:108480687–108480793:-

0.00

13.62

Inf.

1.14E-03

mir-326

chr9:9132229–9132320:-

0.00

5.01

Inf.

4.00E-02

  1. The reads shown in the table are normalized to counts per million calculated by the TMM normalized sample size, the log2 of the fold change (positive for down regulation in the necrotic tissue) and the p-values are determined by the exact-test. A p-value cutoff of 0.05 was applied. The miRNAs marked with (Q) were chosen for RT-qPCR.