Table 1 Functional annotation for most informative genes
From: Transcriptome classification reveals molecular subtypes in psoriasis
BTC | Description: betacellulin |
| Â | Chromosomal region: chr4q13-q21 |
| Â | GO-BP: cell proliferation, positive regulation of cell proliferation |
| Â | GO-MF: epidermal growth factor receptor binding, growth factor activity, growth factor activity |
| Â | GO-CC: extracellular region, soluble fraction, plasma membrane, integral to membrane |
| Â | Pathway: ErbB signalling, ERK signaling |
CNFN | Description: cornifelin |
Chromosomal region: chr19q13.2 | |
GO-BP: keratinization | |
GO-MF: NA | |
GO-CC: cornified envelope, cytoplasm | |
Pathway: NA | |
C20orf11 | Description: Protein C20orf11 (two hybrid-associated protein 1 with RanBPM) (Twa1) |
Chromosomal region: chr20q13.33 | |
GO-BP: NA | |
GO-MF: protein binding | |
GO-CC: nucleus | |
Pathway: NA | |
BUB3 | Description: budding uninhibited by benzimidazoles 3 homolog (yeast) |
Chromosomal region: chr10q26 | |
GO-BP: mitosis, cell proliferation, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle | |
GO-MF: protein binding | |
GO-CC: kinetochore, nucleus, cytosol | |
Pathway: Cell cycle role of APC in cell cycle regulation | |
IL1F7 | Description: interleukin 1 family, member 7 (zeta) |
Chromosomal region: chr2q12-q14.1 | |
GO-BP: immune response | |
GO-MF: cytokine activity, interleukin-1 receptor binding, interleukin-1 receptor antagonist activity | |
GO-CC: extracellular region | |
Pathway: Systemic lupus erythematosus signaling, role of cytokines in mediating communication between immune cells, graft-versus-host disease signaling, p38 MAPK signaling, atherosclerosis signaling |