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Table 1 DNA methylation or alternative splicing in honeybee genes is associated with higher cross-species evolutionary conservation

From: Genome-wide association between DNA methylation and alternative splicing in an invertebrate

 

Proportion of methylated genes

Proportion of unmethylated genes

Methylated vs. unmethylated P-value

Proportion of alternatively spliced genes

Proportion of non-alternatively spliced genes

Alternatively spliced vs. Non-alternatively spliced P-value

Conserved in H. sapiens

0.215

0.082

7.20E-69

0.189

0.13

8.79E-10

Conserved in C. intestinalis

0.142

0.053

1.86E-45

0.125

0.084

2.83E-07

Conserved in A. pisum

0.24

0.136

5.40E-35

0.259

0.159

1.17E-21

Conserved in N. vitripennis

0.426

0.278

9.26E-47

0.445

0.312

1.33E-25

Conserved in D. melanogaster

0.265

0.163

6.22E-31

0.3

0.179

7.23E-28

  1. Cross-species gene conservation was determined by protein BLAST (E-value cutoff of 1E-150). A significantly higher proportion of methylated honeybee genes are conserved across several species and taxa (Homo sapiens, Ciona intestinalis, Acryothisum pisum, Nasonia vitripennis, Drosophila melanogaster) than unmethylated genes (Fisher’s exact test, P-values shown in column 4). Similarly, a significantly higher proportion of alternatively spliced genes are conserved than non-alternatively spliced genes (P-values in column 7). Raw data were the same as for Figure1.