Table 2 Variants in virulence related genes
From: Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300
Gene | Gene ID | Position | Ref base | Alt base | Substitution | Invasive | SSTI |
|---|---|---|---|---|---|---|---|
immunoglobulin G binding protein A precursor | SAUSA300_0113 | 128554 | G | T | N380K | 0 | 1 |
IucC family siderophore biosynthesis protein | SAUSA300_0123 | 142320 | G | T | S404I | 1 | 0 |
sucrose-specific PTS tranporter protein | SAUSA300_0194 | 226384 | C | T | A153V | 1 | 0 |
sucrose-specific PTS tranporter protein | SAUSA300_0194 | 226642 | G | A | G239D | 0 | 1 |
choloylglycine hydrolase family protein | SAUSA300_0269 | 321604 | C | A | P194T | 0 | 1 |
essC protein | SAUSA300_0283 | 336391 | G | A | E142K | 0 | 1 |
essC protein | SAUSA300_0283 | 336694 | A | G | I243V | 1 | 0 |
superantigen-like protein 5 | SAUSA300_0399 | 451121 | C | A | A7E | 1 | 1 |
superantigen-like protein | SAUSA300_0407 | 460962 | TACAG | ----- | Frameshift 108 | 11 | 10 |
dimethyladenosine transferase | SAUSA300_0470 | 530052 | T | A | V258E | 0 | 1 |
clumping factor A | SAUSA300_0772 | 859497 | C | A | A117D | 0 | 1 |
enterotoxin Q | SAUSA300_0801 | 884359 | T | - | Frameshift 142 | 1 | 0 |
cysteine protease precursor | SAUSA300_0950 | 1038844 | A | T | V206E | 0 | 1 |
fmt protein | SAUSA300_0959 | 1051797 | C | T | T269I | 0 | 1 |
alpha-hemolysin precursor | SAUSA300_1058 | 1157169 | G | T | T53N | 0 | 1 |
putative fibronectin/fibrinogen binding protein | SAUSA300_1101 | 1204860 | C | A | D555Y | 0 | 2 |
putative enterotoxin type A | SAUSA300_1559 | 1708640 | C | A | E78* | 1 | 0 |
cell wall surface anchor family protein | SAUSA300_1702 | 1878567 | G | A | P1968S | 1 | 0 |
cell wall surface anchor family protein | SAUSA300_1702 | 1878783 | G | C | Q1896E | 0 | 1 |
cell wall surface anchor family protein | SAUSA300_1702 | 1878930 | C | A | A1847S | 0 | 1 |
cell wall surface anchor family protein | SAUSA300_1702 | 1880436 | C | T | E1345K | 0 | 1 |
cell wall surface anchor family protein | SAUSA300_1702 | 1880783 | G | A | A1229V | 0 | 1 |
serine protease SplA | SAUSA300_1758 | 1943333 | T | C | D113G | 0 | 1 |
lantibiotic epidermin biosynthesis protein EpiC | SAUSA300_1765 | 1950378 | A | G | V209A | 0 | 1 |
lantibiotic epidermin biosynthesis protein EpiB | SAUSA300_1766 | 1953206 | T | - | Frameshift 261 | 0 | 1 |
leukotoxin LukD | SAUSA300_1768 | 1955543 | C | T | V254I | 1 | 0 |
leukotoxin LukE | SAUSA300_1769 | 1957230 | T | C | K4E | 0 | 1 |
Aerolysin/leukocidin family protein | SAUSA300_1975 | 2130674 | G | A | A63V | 1 | 0 |
Aerolysin/leukocidin family protein | SAUSA300_1975 | 2130847 | T | - | Frameshift 5 | 0 | 1 |
hyaluronate lyase precursor | SAUSA300_2161 | 2338286 | G | T | K65N | 0 | 1 |
hyaluronate lyase precursor | SAUSA300_2161 | 2340008 | A | T | L639F | 1 | 0 |
AcrB/AcrD/AcrF family protein | SAUSA300_2213 | 2380381 | - | T | Frameshift 1050 | 0 | 1 |
AcrB/AcrD/AcrF family protein | SAUSA300_2213 | 2382879 | A | T | L218* | 0 | 1 |
teicoplanin resistance associated membrane protein TcaB protein | SAUSA300_2301 | 2473522 | C | G | W311C | 0 | 1 |
IgG-binding protein SBI | SAUSA300_2364 | 2540728 | G | A | E150K | 0 | 1 |
IgG-binding protein SBI | SAUSA300_2364 | 2540773 | C | A | Q165K | 1 | 0 |
IgG-binding protein SBI | SAUSA300_2364 | 2540911 | G | A | V211M | 1 | 1 |
gamma-hemolysin component A | SAUSA300_2365 | 2542364 | C | A | Q80K | 1 | 0 |
gamma-hemolysin component C | SAUSA300_2366 | 2543638 | A | G | I6V | 0 | 1 |
putative transporter | SAUSA300_2406 | 2591556 | A | C | M273R | 2 | 0 |
clumping factor B | SAUSA300_2565 | 2774393 | C | T | G883R | 0 | 1 |