Figure 6From: RNA-Seq and molecular docking reveal multi-level pesticide resistance in the bed bugMolecular modeling and docking of CYP397A1V2 with substrate insecticides. (A) Cartoon representation of the homology model of CYP397A1V2. The cartoon model of CYP397A1V2 is colored using a blue to red gradient from N-terminus to C-terminus. The model was created with MODELLER 9v8 using human cytochrome P450 CYP3A4 as a template. (B) Clipped view of the 'V' shaped molecular surface of the active site cavity. (C-F) Insecticide substrates docked into the binding site of CYP397A1V2 represented as a cartoon model: DDT (C), imidacloprid (D), deltamethrin (E), and permethrin (F), depicted in a stick model (light green). CYP397A1V2 residues interacting with ligand rendered as the line model. The images were made using Pymol pymol.sourceforge.net.Back to article page