Figure 8

Hypoxia increases transcript levels of enzymes involved in terpenoid and ergosterol biosynthesis. A. KEGG heat map representation of genes involved in steroid (ergosterol) biosynthesis and B. terpenoid (isoprenoid) biosynthesis. The median value from three biological replicates was used. If multiple transcripts exist for a given enzymatic step (i.e. HmgA and HmgB for 2.3.3.10), the transcript with the highest amplitude was used. Microarray data compares mRNA levels of wild type A. fumigatus at the indicated times after exposure to hypoxic conditions to time point immediately prior to hypoxia exposure (0 hours). Yellow indicates transcript levels are increased compared to normoxia (0 hours). Blue indicates transcript levels are reduced compared to normoxia (0 hours).