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Figure 1 | BMC Genomics

Figure 1

From: High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome

Figure 1

Visualization of the association between biological significance and statistical significance using volcano plots for the KO (Figure1A), KOd (Figure1B) and OE (Figure1C) datasets. In the plots the X-axis represents the percentage difference in elemental abundance and the Y-axis represents the absolute log of the q-values of the modified Z values. Q-values are the false discovery rate adjusted p-values and range between 0 and 1. Data points are colored in gray if elemental abundances were not statistically altered after gene perturbation. When elemental abundances were statistically altered data points are clustered into three groups according to the percentage difference. The three groups are group A (black dots) with percentage difference between −0.2 and 0.2, group B (blue dots) with percentage difference between −0.5 and −0.2 or between 0.2 and 1, and group C (magenta dots) with differences than −0.5 or greater than 1. Two blue vertical lines and two magenta vertical lines are added to represent the cutoffs for the three groups. The blue and red horizontal lines correspond to the negative and positive cutoff for statistical significance with 95% confidence. Labels of gene name and element names are added to the plots to identify those data points (pink stars) associated with genes from group C of either known function (Table 2) or proposed (Table 3) function in regulating the yeast ionome.

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