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Table 1 Canonical Pathways enriched in mouse, macaque and swine CA04 infection models

From: 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

Infection model

Canonical pathway

B-H p- value

mola/molb

Mouse

Acute Phase Response Signaling

2.34E-10

28/177

 

LXR/RXR Activation

2.34E-10

26/136

 

Atherosclerosis Signaling

3.47E-09

22/129

 

Hepatic Fibrosis / Hepatic Stellate Cell Activation

6.31E-07

21/147

 

IL-12 Signaling and Production in Macrophages

1.12E-06

20/155

 

Complement System

4.07E-06

10/35

 

Type I Diabetes Mellitus Signaling

5.50E-06

17/121

 

Nitrogen Metabolism

8.51E-05

9/120

 

Clathrin-mediated Endocytosis Signaling

1.30E-04

20/195

 

Dendritic Cell Maturation

1.70E-04

18/185

Macaque

VDR/RXR Activation

3.63E-03

13/81

 

Hematopoiesis from Pluripotent Stem Cells

5.25E-03

10/64

 

Communication between Innate and Adaptive Immune Cells

2.75E-02

12/109

 

Type I Diabetes Mellitus Signaling

3.16E-02

13/121

 

Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

3.80E-02

11/92

 

Gα12/13 Signaling

3.80E-02

13/127

 

Neuroprotective Role of THOP1 in Alzheimer's Disease

3.80E-02

7/54

 

Hematopoiesis from Multipotent Stem Cells

3.80E-02

4/12

 

Primary Immunodeficiency Signaling

3.80E-02

8/63

 

Pyrimidine Metabolism

3.80E-02

14/215

Swine

LXR/RXR Activation

1.15E-07

20/136

 

Nitrogen Metabolism

9.33E-04

8/120

 

Antigen Presentation Pathway

9.33E-04

8/40

 

Communication between Innate and Adaptive Immune Cells

9.33E-04

12/109

 

Hepatic Fibrosis / Hepatic Stellate Cell Activation

9.33E-04

15/147

 

Type I Diabetes Mellitus Signaling

9.33E-04

13/121

 

Primary Immunodeficiency Signaling

9.33E-04

9/63

 

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

9.33E-04

12/106

 

TREM1 Signaling

9.33E-04

9/66

 

Atherosclerosis Signaling

1.12E-03

13/129

  1. Ingenuity Pathway Analysis was used to determine the top 10 Canonical Pathways. Benjamini-Hochberg (B-H) Multiple Testing Correction p-value was used to rank the significance associated for each pathway.
  2. a Number of molecules differentially expressed in the Canonical Pathway.
  3. b Total number of molecules in the annotated Canonical Pathway.