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Table 2 Upstream Regulator analysis of mouse, macaque and swine CA04 infection models

From: 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

Upstream regulator

Molecule type

p-value of overlap

Regulation z-score (dpi)

Predicted regulator status

Mouse

    

 STAT3

transcription regulator

1.68E-17

  

 STAT1

transcription regulator

2.80E-17

2.747 (3); 2.124 (5)

Activated

 PPARA

ligand-dependent nuclear receptor

1.12E-15

  

 NFκB (complex)*

complex

2.37E-13

2.463 (3); 2.787 (5)

Activated

 JUN

transcription regulator

6.74E-13

2.072 (5)

Activated

 YY1

transcription regulator

4.65E-12

  

 SMAD3

transcription regulator

5.13E-12

  

 IRF7

transcription regulator

3.52E-11

2.994 (3); 2.532 (5)

Activated

 IRF1

transcription regulator

4.14E-11

2.125 (3)

Activated

 HNF1A*

transcription regulator

5.01E-11

-3.166 (1); -3.743 (3); -3.035 (5)

Inhibited

Macaque

    

 IRF1

transcription regulator

2.16E-10

2.547 (1)

Activated

 SPI1

transcription regulator

4.74E-08

2.490 (1)

Activated

 TRIM24

transcription regulator

2.43E-07

-3.395 (1, 6)

Inhibited

 IRF7

transcription regulator

4.98E-07

4.284 (1, 6)

Activated

 STAT3

transcription regulator

4.31E-06

2.096 (1, 6)

Activated

 STAT1

transcription regulator

1.15E-05

3.232 (1); 3.57 (6)

Activated

 JUN

transcription regulator

1.57E-05

  

 IRF8

transcription regulator

7.08E-05

  

 VitaminD3-VDR-RXR

complex

7.75E-05

  

 ELF1

transcription regulator

9.71E-05

  

Swine

    

 STAT1*

transcription regulator

6.54E-14

2.823 (3); 3.157 (5)

Activated

 TRIM24

transcription regulator

2.59E-11

  

 IRF1*

transcription regulator

7.54E-11

  

 PPARA

ligand-dependent nuclear receptor

2.34E-09

-2.001 (3)

Inhibited

 STAT3

transcription regulator

2.35E-09

  

 NFκB complex

complex

2.48E-09

3.01 (5)

Activated

 IRF2*

transcription regulator

7.64E-09

  

 IRF7

transcription regulator

1.52E-08

  

 JUN

transcription regulator

4.38E-08

  

 NFKB1

transcription regulator

2.32E-07

2.136 (7)

Activated

  1. Ingenuity Pathway Analysis was used to determine the top 10 Upstream Regulators. The p-value of overlap was used to rank the significance associated for each Upstream Regulator. The p-value indicates the significance of the overlap between the genes targeted by the upstream regulator in the IPKB database and the experimental dataset. Genes with an apteryx signify regulators that were identified as significantly enriched (P < 0.0001) by PSCAN. Z-scores for predicted upstream regulators (|z|>2) in each species and at each time point are shown. Z > 2 predicts activation of the upstream regulator. Z < -2 predicts inhibition of the upstream regulator.
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BMC Genomics

ISSN: 1471-2164

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