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Table 5 Top GO enrichment terms for methylation modules

From: Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects

Module

Size

Rank

p.Bonf

Fraction

Ontology

Term name

32

1067

1

4.20E-09

0.1875

CC

extracellular region

1

1045

1

8.20E-16

0.790123

CC

intracellular

1

1045

3

1.50E-11

0.083333

CC

ribonucleoprotein complex

30

616

1

2.50E-21

0.34687

BP

anatomical structure development

30

616

2

1.60E-18

0.189509

BP

nervous system development

7

594

1

8.30E-10

0.157424

BP

immune system process

7

594

2

9.10E-10

0.177102

MF

receptor activity

3

427

1

3.20E-12

0.259947

CC

extracellular region

12

130

1

0.0032

0.075

BP

DNA recombination

2

105

1

1.70E-10

0.191919

BP

lymphocyte activation

2

105

2

2.30E-10

0.20202

BP

leukocyte activation

2

105

3

3.60E-10

0.323232

BP

immune system process

  1. For each module we list the top enriched GO terms. Columns list the module label, module size, rank of the enrichment p-value for that particular module, the Bonferroni-corrected enrichment p-value (the correction is performed with respect to the number of GO terms), fraction of the module genes also in the GO term, GO ontology, and GO term name. Multiple methylation modules exhibit significant enrichment. Row shading separates modules for easier reading. Again, the enrichment provides evidence that the modules are biologically meaningful.