Transcriptome analysis reveals unique metabolic features in the Cryptosporidium parvum Oocysts associated with environmental survival and stresses

Table 4 Functional categorization of significantly regulated genes in the oocysts upon UV irradiation

Group 0.5 h	Up	Up	Up	Mid	Mid	Mid	Down	Down	Down	No. Total	% Total
Group 5.0 h	Up	Mid	Down	Up	Mid	Down	Up	Mid	Down	No. Total	% Total
Cluster	1	2	3	4	5	6	7	8	9
Enzyme	2	25	0	15	149	16	0	19	1	227	12.24
RNA metabolism	0	18	0	2	65	2	0	8	3	98	5.28
Gene expression	0	9	1	1	57	1	0	10	1	80	4.31
Ribosome biogenesis	0	7	0	0	74	0	0	7	4	92	4.96
Transporter	0	15	0	3	44	3	0	6	0	71	3.83
Membrane	0	6	0	1	24	3	0	4	0	38	2.05
DNA metabolism	2	9	0	0	33	1	0	2	0	47	2.53
Protein degradation	0	2	0	6	32	0	1	3	0	44	2.37
Structure	2	4	0	0	16	2	0	1	0	25	1.35
Chaperonin	1	2	0	2	18	2	0	2	0	27	1.46
Cell cycle	0	5	0	1	7	0	0	1	0	14	0.75
Chromatin	1	4	0	0	12	0	0	0	0	17	0.92
Redox homeostasis	0	2	0	0	12	1	0	1	0	16	0.86
Mitochondrial	0	4	0	0	5	0	0	1	1	11	0.59
General	0	0	0	1	2	0	0	1	0	4	0.22
Total annotatable	8	112	1	32	550	31	1	66	10	811	43.72
Unknown function	23	124	5	68	633	46	10	118	17	1044	56.28
Grand Total	31	236	6	100	1183	77	11	184	27	1855	100.00

Note: Up = up-regulated (fold changes >1.2), Mid = less significantly regulated “middle” group (fold changes between 0.8 to 1.2), Down = down-regulated (fold changes <0.8).

ISSN: 1471-2164