Figure 2
GWA results for mitochondrial respiration and efficiency. Significant SNPs (P ≤ 1×10-5) are plotted. The top panel shows the minor allele frequency (MAF) for each significant SNP. P-values are plotted as -Log10 (P) in the middle panel. Effect size normalized to genotypic standard deviation is plotted in the bottom panel. The lower triangle shows the distribution of linkage disequilibrium among SNPs as r2. Solid black lines identify the five major chromosome arms. (Panel A) State 3 respiration rates. (Panel B) State 4 respiration rates. (Panel C) P:O ratio.