Skip to main content

Table 4 Experimentally validated miRNA-related SNPs found in MirSNP

From: MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs

MiRNA

Target gene

Functional SNP

Reported associated disease

MirSNP

PolymiRTS2

Mirsnpscore

Patrocles

Pubmed id

Journal

Author

hsa-mir-629

NBS1

rs2735383

Lung cancer

    

22114071

Carcinogenesis

Yang L

hsa-mir-184

TNFAIP2

rs8126

Squamous cell carcinoma of the head and neck

✓

✓

  

21934093

Carcinogenesis

Liu Z

hsa-mir-1827

MYCL1

rs3134615

Small-cell lung cancer

✓

 

✓

✓

21676885

Cancer Res

Xiong F

hsa-mir-148a

HLA-C

rs67384697

HIV

✓

   

21499264

Nature

Kulkarni S

hsa-mir-191

MDM4

rs4245739

Ovarian carcinomas

✓

 

✓

 

21084273

Cancer Res

Wynendaele J

hsa-mir-125b

BMPR1B

rs1434536

Breast cancer

✓

✓

✓

✓

19738052

Cancer Res

Saetrom P

hsa-mir-510

HTR3E

rs56109847

Diarrhea predominant irritable bowel syndrome

✓

✓

  

18614545a

Hum. Mol. Genet

Kapeller J

hsa-mir-96

HTR1B

rs13212041

Arson or property damage

    

18283276a

Mol. Psychiatry

Jensen KP

hsa-mir-433

FGF20

rs12720208

Parkinson’s disease

✓

 

✓

 

18252210a

Am. J. Hum. Genet

Wang G

hsa-mir-148/152

HLA-G

rs1063320

Childhood asthma

✓

✓

✓

✓

17847008a

Am. J. Hum. Genet

Tan Z

hsa-mir-24

DHFR

rs34764978

Methotrexate resistance

    

17686970a

PNAS

Mishra PJ

hsa-mir-155

AGTR1

rs5186

Hypertension

✓

✓

  

17668390a

Am. J. Hum. Genet

Sethupathy P

hsa-mir-206

ESR1

rs9341070

Breast cancer

    

17312270a

Mol. Endocrinol

Adams BD

hsa-mir-24

SLITRK1

rs193302862

Tourette’s syndrome

✓

   

16224024a

Science

Abelson JF

  1. Some cases are not in MirSNP because the SNPs were not located in the 3’UTR based on our records (rs34764978, rs13212041) or do not have a perfect 7-nt binding in the seed site (rs2735383, rs9341070).
  2. aThese cases are from Table 2 in Sethupathy and Collins [34].