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Table 3 Differentially regulated genes in eight deletions

From: Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library

Systematic ID

Gene name

Description of gene products

2C

1C

W4C

S4C

Gene ontology

   

ash2 Δ

SPAC3F10.17 Δ

SPBC2A9.02 Δ

SPAC27D7.08c Δ

sgf73 Δ

meu29 Δ

sec65 Δ

pab1 Δ

 

SPAC14C4.09

agn1 +

glucan endo-1,3-alpha-glucosidase

2.7

2.0

2.4

1.9

2.6

1.9

2.9

3.1

cell septum edging catabolic process

SPAC6G10.12c

ace2 +

transcription factor

4.1

3.8

1.3

1.4

2.4

1.6

3.9

3.4

cytokinetic cell separation

SPAC821.09

eng1 +

endo-1,3-beta-glucanase

5.7

4.1

1.5

1.1

3.1

4.2

6.3

5.9

primary cell septum disassembly

SPBC83.18c

fic1 +

C2 domain protein

1.8

1.6

1.3

1.3

2.3

1.9

1.3

1.3

cell cycle cytokinesis

SPCC320.13c

ark1 +

aurora-B kinase

1.4

1.4

1.2

1.5

2.7

2.3

1.5

1.3

cell cycle cytokinesis

SPAC17H9.19c

cdt2 +

WD repeat protein

2.6

1.4

3.3

1.6

2.5

1.2

2.2

3.0

DNA replication checkpoint

SPAC1F7.05

cdc22 +

ribonucleoside reductase large subunit

2.7

2.3

2.1

1.6

3.3

2.3

2.5

2.8

regulation of DNA-dependent DNA replication

SPAC27E2.10c

rfc3 +

DNA replication factor C complex subunit

1.7

1.2

1.1

1.1

1.6

2.1

1.3

1.3

DNA-dependent DNA replication

SPAC3G6.06c

rad2 +

FEN-1 endonuclease

0.98

1.8

1.6

1.6

2.1

2.5

1.7

1.7

DNA replication, removal of RNA primer

SPAC821.08c

slp1 +

sleepy homolog

2.6

2.2

1.2

1.2

3.6

2.0

2.5

2.2

DNA replication checkpoint

SPBC1105.04c

abp1 +

CENP-B homolog

0.64

0.69

0.43

0.40

0.41

0.46

0.57

0.52

DNA-dependent DNA replication initiation

SPBC12D12.02c

cdm1 +

DNA polymerase delta subunit

1.9

2.2

1.5

1.9

1.9

1.3

2.8

3.1

DNA strand elongation involved in DNA replication

SPBC14C8.07c

cdc18 +

MCM loader

1.9

1.4

1.4

1.0

2.3

1.2

2.0

1.9

DNA replication checkpoint

SPBC1861.02

abp2 +

ARS binding protein

1.5

1.2

0.28

0.50

0.31

0.70

0.91

0.80

DNA-dependent DNA replication initiation

SPBC428.18

cdt1 +

replication licensing factor

3.0

2.8

2.3

1.7

2.2

2.2

3.5

3.3

DNA replication checkpoint

SPBC660.14

mik1 +

mitotic inhibitor kinase

2.5

3.2

1.5

1.5

3.4

1.7

2.3

2.4

DNA replication checkpoint

SPCC1672.02c

sap1 +

switch-activating protein

1.2

0.75

1.6

1.0

2.3

1.2

1.4

1.4

replication fork arrest at rDNA repeats

SPCC23B6.05c

ssb3 +

DNA replication factor A subunit

2.1

1.8

1.1

1.6

1.3

1.4

1.2

1.3

DNA-dependent DNA replication

SPCC970.10c

brl2 +

ubiquitin-protein ligase E3

2.6

1.3

1.1

0.89

1.1

1.2

1.1

1.1

DNA replication-independent nucleosome assembly

  1. Differentially regulated genes in the deletions comparing to WT were analyzed using an Affymetrix microarray. Genes relevant to DNA replication and cytokinesis are listed. The number represents the ratio of mRNA level in the deletion relative to that in WT.