Table 2 Similarities between yeast and human SCD proteins

Dna2*

(DNA2)

Nuclease and helicase required for Okazaki fragment processing; involved in DNA repair.

Fkh2

(FOXJ3)

Transcription factor with a major role in the expression of G2/M phase genes.

Gcn2*

(EIF2AK4)

Protein kinase, phosphorylates eIF2 (Sui2p) in response to starvation; contributes to DNA damage checkpoint control.

Pol5

(MYBBP1A)

DNA Polymerase phi; not required for chromosomal DNA replication; required for the synthesis of rRNA.

Nup100/116

(POM121)

Subunit of the nuclear pore complex (NPC); interacts with mRNA export factor Mex67p and with Kap95p.

Rad54*

(RAD54L)

Involved in the recombinational repair of double-strand breaks.

Rfx1

(RFX1)

Major transcriptional repressor of DNA-damage-regulated genes.

Smc2

(SMC2)

Subunit of the condensin complex.

Taf9**

(TAF9B)

Subunit of TFIID and SAGA complexes.

Tif4631*

(EIF4G2)

Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F).

Selection of yeast SCD genes whose human ortholog contains phosphorylated S/T-Q sites

Bub1

(BUB1)

Protein kinase that play crucial roles in the Spindle Assembly Checkpoint.

Cdc20

(CDC20)

Cell-cycle regulated activator of APC/C, which is required for metaphase/anaphase transition.

Cdc4

(FBXW7)

F-box protein that controls cell cycle function, sulfur metabolism, and methionine biosynthesis.

Hrr25

(CSNK1D)

Protein kinase involved in regulating vesicular trafficking, DNA repair, and chromosome segregation.

Mad1

(MAD1)

Coiled-coil protein involved in the spindle-assembly checkpoint.

Mcm1

(SRF)

Transcription factor involved in cell-type-specific transcription and pheromone response.

Mcm6

(MCM6)

Protein involved in DNA replication; component of the Mcm2-7 hexameric pre-replicative complex.

Mih1*

(CDC25A)

Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p.

Mlh1**

(MLH1)

Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis.

Msh3

(MSH3)

Mismatch repair protein.

Pds5**

(APRIN)

Protein required for establishment and maintenance of sister chromatid condensation and cohesion.

Sch9

(RPS6KA1)

Kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression.

Tid3**

(NDC80)

Part of the kinetochore-associated Ndc80 complex involved in chromosome segregation.

Ubr1

(UBR1)

E3 ubiquitin ligase (N-recognin) that ubiquitinate substrates in the N-end rule pathway.

Ycs4**

(NCAPD2)

Subunit of the condensin complex.

Selection of yeast SCD genes whose human ortholog contains an SCD and is known to be phosphorylated in S/T-Q sites

Akl1*

(AAK1)

Protein kinase involved in endocytosis and actin cytoskeleton organization.

Bni1

(FMN2)

Formin, nucleates the formation of linear actin filaments; involved in and mitotic spindle orientation.

Cdc3**

(SEP6*)

Component of the septin ring of the mother-bud neck that is required for cytokinesis.

Ctf18**

(CHTF18)

Required for sister chromatid cohesion; part of the DNA damage replication checkpoint.

Exo1

(EXO1*)

5^′-3^′ exonuclease and flap-endonuclease involved in recombination, DSB and mismatch repair.

Pol2

(POLE)

Catalytic subunit of DNA polymerase (II) epsilon.

Rad50*

(RAD50*)

Subunit of MRX complex involved in processing double-strand DNA breaks, and telomere maintenance.

Rts1

(PPP2RA*)

Regulatory subunit of protein phosphatase 2A (PP2A).

Tom1**

(HUWE1*)

E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus.