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Table 1 Types of transcriptional responses observed following ligand activation of PPARβ/δ in mouse primary keratinocytes

From: Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4

Type

Without exogenous ligand

With exogenous ligand

I

Repression

II

Activation

III

Activation

IV

Repression

V

Repression

Activation

VI

Activation

Repression

VII

Activation

Activation

VIII

Repression

Repression

  1. The effect without exogenous ligand reflects the response in expression of a particular gene observed in control Pparβ/δ-null keratinocytes as compared to control wild-type keratinocytes. For this column, repression indicates that gene expression is higher in Pparβ/δ-null cells as compared to wild-type cells and activation indicates that gene expression is lower in Pparβ/δ-null cells as compared to wild-type cells. The effect with exogenous ligand reflects the response in expression of a particular gene observed in wild-type keratinocytes treated with the highly specific PPARβ/δ ligand GW0742 as compared to control wild-type keratinocytes. For this column, activation indicates that gene expression is higher in GW0742-treated wild-type cells as compared to control wild-type cells and repression indicates that gene expression is lower in GW0742-treated wild-type cells as compared to control wild-type cells.