Type | Without exogenous ligand | With exogenous ligand |
---|
I | Repression | – |
II | Activation | – |
III | – | Activation |
IV | – | Repression |
V | Repression | Activation |
VI | Activation | Repression |
VII | Activation | Activation |
VIII | Repression | Repression |
- The effect without exogenous ligand reflects the response in expression of a particular gene observed in control Pparβ/δ-null keratinocytes as compared to control wild-type keratinocytes. For this column, repression indicates that gene expression is higher in Pparβ/δ-null cells as compared to wild-type cells and activation indicates that gene expression is lower in Pparβ/δ-null cells as compared to wild-type cells. The effect with exogenous ligand reflects the response in expression of a particular gene observed in wild-type keratinocytes treated with the highly specific PPARβ/δ ligand GW0742 as compared to control wild-type keratinocytes. For this column, activation indicates that gene expression is higher in GW0742-treated wild-type cells as compared to control wild-type cells and repression indicates that gene expression is lower in GW0742-treated wild-type cells as compared to control wild-type cells.