Weighted pedigree-based statistics for testing the association of rare variants

BMC Genomics

Table 3 Power of mixed and unmixed study designs

	Sample Size and Power
Uniform Data Design
Sib-Pair-2	900	1200	1500	1800	2100
χ²	0.37	0.48	0.52	0.55	0.57
Collapsing	0.51	0.58	0.62	0.66	0.69
VT	0.6	0.68	0.73	0.77	0.79
WSS	0.61	0.7	0.74	0.78	0.81
Nuclear Family 2	900	1200	1500	1800	2100
χ²	0.40	0.50	0.54	0.57	0.59
Collapsing	0.52	0.60	0.64	0.67	0.70
VT	0.62	0.70	0.76	0.79	0.80
WSS	0.63	0.72	0.78	0.81	0.82
Three Generation 2	900	1200	1500	1800	2100
χ²	0.44	0.53	0.57	0.6	0.63
Collapsing	0.54	0.62	0.67	0.7	0.73
VT	0.64	0.71	0.79	0.82	0.84
WSS	0.65	0.74	0.8	0.84	0.85
Mixed Data Designs
Mix1 (33% Sib-Pair-2, 33% nuclear-2, and 34% Three- generation-2)	900	1200	1500	1800	2100
χ²	0.39	0.51	0.53	0.56	0.60
Collapsing	0.53	0.59	0.64	0.68	0.70
VT	0.62	0.68	0.73	0.77	0.82
WSS	0.62	0.69	0.75	0.81	0.84
Mix2 (50% Sib-Pair-2 and 50% Nuclear Family-2)	900	1200	1500	1800	2100
χ²	0.36	0.45	0.50	0.55	0.58
Collapsing	0.49	0.55	0.59	0.63	0.65
VT	0.59	0.68	0.74	0.78	0.82
WSS	0.6	0.69	0.76	0.8	0.83

ISSN: 1471-2164