Table 2 Time-dependent elicitation of cytokine and signaling pathway by TSA in H9c2 cells*
Control versus TSA (6 h) | Control versus TSA (24 h) | ||
|---|---|---|---|
Gene pathway | Total connections (No. of focus genes) | Gene pathway | Total connections (No. of focus genes) |
TGFβ1 | 33 (16) | TGFβ1 | 29 (18) |
HNF4A | 30 (14) | HNF4A | 30 (12) |
MyC | 30 (12) | ERK-p38-JNK | 56 (10) |
PTEN-PI3K-Akt | 53 (11) | TP53 | 33 (10) |
TNF-α | 35 (10) | TNF-.α | 30 ( 8 ) |
NFκΒ | 33 (10) | FOS | 28 ( 8 ) |
p38-JNK | 45 ( 9 ) | CDKN1A | 12 ( 8 ) |
IFNγ | 32 ( 9 ) | NFκΒ | 29 ( 3 ) |
Caspase 3 | 28 ( 8 ) | Calcium | 28 ( 3 ) |
CDKN2A | 10 ( 8 ) | AP1 | 18 ( 3 ) |
Calcium | 31 ( 6 ) | CaMKII | 10 ( 3 ) |
Insulin | 22 ( 6 ) | Caspase 3 | 16 ( 2 ) |
TP53 | 20 ( 5 ) | ||