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Table 2 Comparison of the performances by different machine learning algorithms

From: Improving ChIP-seq peak-calling for functional co-regulator binding by integrating multiple sources of biological information

 

Number of peaks

Number of peaks with ERE motif

Ratio of peaks with ERE motif match

MACS p = 1E-10

1,286

941

0.73

MACS p = 1E-8

1,966

1,416

0.72

MACS p = 1E-5

4,678

3,077

0.66

k-means (city block)

Cluster 1

26,211

11,943

0.46

Cluster 2

12,113

3,245

0.27

supervised-NB(th = 0.8,1:2)

Positively labeled

11,835

8,196

0.69

Negatively labeled

26,489

6,992

0.26

supervised-SVM(kernel = polynomal,1:2)

Positively labeled

14,915

8,425

0.56

Negatively labeled

23,409

6,763

0.29

supervised-RF(th = 0.7,1:2)

Positively labeled

10,428

6,514

0.62

Negatively labeled

27,896

8,674

0.31

semi-supervised-NB(th = 0.8,1:2, I = 75)

Positively labeled

12,597

8,458

0.67

Negatively labeled

25,727

6,730

0.26