Differential combinatorial regulatory network analysis related to venous metastasis of hepatocellular carcinoma

BMC Genomics

Table 3 Enriched KEGG non-metabolic pathways of the 17 key regulatory modules.

Module name	KEGG pathway	P value
FOXO3_NM	03050~Proteasome	0.0342
	05213~Endometrial cancer	0.0213
	05223~Non-small cell lung cancer	0.0221
TP53_NM	04110~Cell cycle	0.039
	04115~p53 signaling pathway	0.0212
	04210~Apoptosis	0.027
	04310~Wnt signaling pathway	0.0459
	04722~Neurotrophin signaling pathway	0.0384
	05014~Amyotrophic lateral sclerosis (ALS)	0.0163
	05210~Colorectal cancer	0.0191
	05212~Pancreatic cancer	0.0215
	05213~Endometrial cancer	0.016
	05214~Glioma	0.02
	05215~Prostate cancer	0.0273
	05216~Thyroid cancer	0.009
	05217~Basal cell carcinoma	0.0169
	05218~Melanoma	0.0218
	05219~Bladder cancer	0.013
	05220~Chronic myeloid leukemia	0.0224
	05222~Small cell lung cancer	0.0258
	05223~Non-small cell lung cancer	0.0166
hsa_miR_16_M	04330~Notch signaling pathway	0.024
	04370~VEGF signaling pathway	0.0386
	04662~B cell receptor signaling pathway	0.0381
hsa_let_7e_M	04210~Apoptosis	0.0181
	04722~Neurotrophin signaling pathway	0.0258
hsa_miR_30a_M	04140~Regulation of autophagy	0.0425
	04144~Endocytosis	0.0264
STAT1_M	03440~Homologous recombination	0.0086
	04062~Chemokine signaling pathway	0.0385
	04620~Toll-like receptor signaling pathway	0.0209
	04630~Jak-STAT signaling pathway	0.0317
	05212~Pancreatic cancer	0.0144

One-sided Fisher's Exact Test was used to test whether the genes in a module were significantly enriched in any KEGG non-metabolic pathways. Six modules (FOXO3_NM, TP53_NM, hsa_miR_16_M, hsa_miR_30a_M, hsa_let_7e_M, STAT1_M) of which the resultant p values less than 0.05 are included in this table.

ISSN: 1471-2164