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Table 4 Functional enrichment analysis of CNVRs

From: Analysis of copy number variations in the sheep genome using 50K SNP BeadChip array

Molecular function

GO Name

Count

%

Pvalue

FDR

GO:0004984

olfactory receptor activity

178

32.07207

5.862E-158

8.27E-155

GO:0034212

peptide N-acetyltransferase activity

3

0.540541

0.006224705

8.432901467

GO:0004596

peptide alpha-N-acetyltransferase activity

3

0.540541

0.006224705

8.432901467

GO:0005344

oxygen transporter activity

4

0.720721

0.007951513

10.65236765

GO:0005218

intracellular ligand-gated calcium channel activity

3

0.540541

0.01014878

13.40426119

GO:0005219

ryanodine-sensitive calcium-release channel activity

3

0.540541

0.01014878

13.40426119

GO:0042043

neurexin binding

3

0.540541

0.020398884

25.23210706

GO:0004683

calmodulin-dependent protein kinase activity

4

0.720721

0.026734392

31.7727638

Biological Process

GO Name

Count

%

P value

FDR

GO:0007608

sensory perception of smell

179

32.25225

1.284E-157

2.15E-154

GO:0007606

sensory perception of chemical stimulus

179

32.25225

6.6567E-148

1.11E-144

GO:0007600

sensory perception

181

32.61261

4.4745E-105

7.48E-102

GO:0050890

cognition

185

33.33333

3.8912E-100

6.51E-97

GO:0007186

G-protein coupled receptor protein signaling pathway

189

34.05405

2.47502E-87

4.14E-84

GO:0050877

neurological system process

193

34.77477

3.0364E-85

5.08E-82

GO:0007166

cell surface receptor linked signal transduction

201

36.21622

5.69264E-59

9.52E-56

GO:0051258

protein polymerization

9

1.621622

0.000194423

0.324648125

GO:0007018

microtubule-based movement

11

1.981982

0.00446377

7.208705512

GO:0015671

oxygen transport

4

0.720721

0.008202995

12.8682872

GO:0051225

spindle assembly

4

0.720721

0.017671563

25.78281061

GO:0015669

gas transport

4

0.720721

0.020691633

29.50783311

GO:0007158

neuron adhesion

3

0.540541

0.020837821

29.68360693

GO:0035176

social behavior

4

0.720721

0.023976546

33.35959701

GO:0044065

regulation of respiratory system process

3

0.540541

0.034182249

44.10238982

GO:0002087

regulation of respiratory gaseous exchange by neurological system process

3

0.540541

0.034182249

44.10238982

GO:0007625

grooming behavior

3

0.540541

0.049984805

57.57958749

Cellular Component

GO Name

Count

%

P value

FDR

GO:0005886

plasma membrane

241

43.42342

5.86933E-35

7.69E-32

GO:0016021

integral to membrane

289

52.07207

1.23979E-32

1.62E-29

GO:0031224

intrinsic to membrane

293

52.79279

1.36024E-31

1.78E-28

GO:0005833

hemoglobin complex

4

0.720721

0.005887046

7.444488585

Pathway

Pathway name

Count

%

P value

FDR

hsa04740

Olfactory transduction

170

30.63063

2.80E-137

3.05E-134

hsa05130

Pathogenic Escherichia coli infection

8

1.441441

0.027376

25.8675045

OMIM_DISEASE

 

Count

%

P value

FDR

Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study

3

0.540541

0.011938

12.52341992

Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study

3

0.540541

0.026364

25.7439374

C1r/C1s deficiency, combined

2

0.36036

0.034033

32.00636058

  1. Abbreviation: FDR, false discovery rate (Benjamini and Hochberg method).