Figure 2
Proximal Estradiol-responsive genes and carrier ERα ChIP-seq enrichment. A. Estradiol up- (white) and down-regulated (black) genes were interrogated for proximal ERα binding events under saturated conditions with 20*106 cells (right), as well as ChIP-seq on 10,000 cells without (left) and with mRNA/histones carrier (middle). The percentage of E2-reponsive genes with a proximal ERα binding site is shown. B. ERα binding events with mRNA/histones carriers were ranked and proximal E2-upregulated genes were determined for the top 10 highest intensity binding sites. Heatmap indicates tag count.