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Table 2 Survival of EcoR1 s mutants after exposure to MMS, bleomycin or gamma radiation a

From: A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae

Mutant

MMS (mM)

bleo (μg/ml)

Γ (krads)

Mutant

MMS (mM)

bleo (μg/ml)

Γ (krads)

 

1

2

2

4

30

60

 

1

2

2

4

30

60

RAD52 group:

rad50

SS

SS

SS

SS

SS

SS

rad55

SS

SS

R

SS

SS

SS

rad51

SS

SS

SS

SS

SS

SS

rad57

SS

SS

R

SS

SS

SS

rad52

SS

SS

SS

SS

SS

SS

mre11

SS

SS

SS

SS

SS

SS

rad54

SS

SS

SS

SS

SS

SS

xrs2

SS

SS

SS

SS

SS

SS

New EcoRIs mutants:

adk1

R

R

SS

SS

R

R

mrps35

R

S

R

S

R

S

ado1

S

S

SS

SS

S

S

not5

R

R

R

R

R

R

akr1

R

R

R

R

R

S

nup8

R

S

S

SS

R

R

apq13

S

SS

S

SS

R

R

och1

R

S

S

SS

R

R

arp5

R

S

R

R

R

S

psy1

R

R

R

R

R

R

atp2

S

SS

S

S

R

R

rad5

SS

SS

S

SS

R

R

bck1

S

SS

R

R

R

S

rem50

R

SS

R

S

R

R

bik1

R

R

R

R

R

R

rpb9

R

SS

S

SS

S

SS

bud19

S

S

SS

SS

S

SS

rpl31a

R

R

R

R

R

R

bud30

R

R

S

S

S

S

rsm7

R

R

S

SS

R

R

bud32

R

R

SS

SS

S

SS

rtf1

R

S

R

SS

S

SS

bur2

R

S

R

R

R

R

rvs161

R

R

R

SS

R

S

cax4

R

R

SS

SS

S

SS

sae2

R

S

R

S

R

S

ccr4

R

R

S

SS

R

R

sam37

S

SS

S

SS

R

R

cdc4

SS

SS

SS

SS

SS

SS

sco1

R

R

R

R

R

R

cgi121

R

R

S

S

SS

SS

sfp1

R

R

R

S

R

R

cis3

S

SS

R

S

R

R

slm4

S

SS

S

SS

R

R

cnm67

R

S

R

SS

S

SS

spt10

R

S

SS

SS

SS

SS

ctf4

SS

SS

R

S

R

R

spt20

R

R

S

SS

R

R

ctf8

S

SS

R

S

R

S

srv2

R

R

R

R

R

R

dcc1

S

SS

R

S

R

R

taf14

S

SS

R

S

R

R

ddc1

R

SS

R

R

R

R

trm9

S

S

S

S

R

R

eaf1

R

S

R

S

S

S

tsr2

R

R

R

S

R

S

exo1

R

R

R

R

S

S

ubp8

R

R

R

R

R

R

gcn5

R

SS

R

S

R

R

ubr1

S

S

R

S

SS

SS

gnd1

S

S

R

SS

S

SS

ume6

R

R

R

R

R

S

hsp150

R

R

R

R

R

R

vma

S

S

SS

SS

S

SS

htl1

R

S

SS

SS

SS

SS

vph2

R

R

SS

SS

R

R

ids2

R

R

R

R

R

S

ybr099c

S

SS

R

R

R

R

img2

R

R

R

S

R

R

ydr417c

S

SS

S

SS

R

R

lip5

R

R

R

S

S

SS

ydr433w

R

SS

SS

SS

R

R

lrp1

R

R

R

S

R

R

ygl218w

R

R

R

R

R

R

lsm7

S

S

R

S

R

S

ylr235c

SS

SS

R

S

R

S

mct1

S

SS

R

S

S

SS

yml009w-b

S

SS

R

S

R

R

mms2

S

SS

R

R

R

R

yml012c-a

S

SS

R

S

R

R

mms22

SS

SS

R

S

S

S

ynr068c

SS

SS

S

SS

R

R

mms4

S

SS

R

R

R

R

       
  1. a Mutants were ranked as resistant (R), sensitive (S), or strongly sensitive (SS). Mutants classified as SS exhibited > 25-fold higher killing than wildtype cells using semi-quantitative dilution pronging assays. Γ, gamma radiation.