Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes

Dmitriev, Petr; Barat, Ana; Polesskaya, Anna; O’Connell, Mary J; Robert, Thomas; Dessen, Philippe; Walsh, Thomas A; Lazar, Vladimir; Turki, Ahmed; Carnac, Gilles; Laoudj-Chenivesse, Dalila; Lipinski, Marc; Vassetzky, Yegor S

doi:10.1186/1471-2164-14-265

Table 1 microRNAs (MR-miRs) found to be up- and downregulated during myogenic differentiation in this study

From: Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes

	microRNA	This study	Human (homo sapiens)	Mouse (Mus musculus)	Pig	Common carp
1	miR-1	↑↑↑	enriched in sk. muscle[15] ↑pMyo diff. [26] ↑ muscle development [30]	↑ C2C12 diff [7, 8, 10, 33] ↑ pMyo diff [33]	↑ muscle development [31]	↑ muscle development [32]
2	miR-15a	↑↑	(this study)	↓ pMyo diff [33]	↑ muscle development [31]
3	miR-16	↓	(this study)	↓ C2C12 diff [33] ↓ pMyo diff [33]	↑ muscle development [31]
4	miR-21	↑	↑ pMyo diff. [26]	-		↑ muscle development [32]
5	miR-22	↑	(this study)	↑ C2C12 diff [33] ↑ pMyo diff [33]	↑ muscle development [31]
6	miR-23b (n)	↑	(this study)
7	miR-24	↑	↑pMyo diff. [26]	↑pMyo diff, ↑ C2C12 diff [11, 33] ↑ C2C12 diff [28, 33]		enriched in heart [32]
8	miR-26a	↑	↑pMyo diff. [26]	↑ C2C12 diff [12, 28] ↑ pMyo diff [33]		↑ muscle development [32]
9	miR-27a	↑	↑pMyo diff. [26]	↑ pMyo diff [33]	↑ muscle development [31]	↓ muscle development [32]
10	miR-27b	↑	(this study)	↑ pMyo [13, 33] ↑ C2C12 diff [28, 33]
11	miR-28 (n)	↑	(this study)	-
12	miR-29a	↓	(this study)	↓ C2C12 diff [28] ↑ C2C12 diff [33]
13	miR-30a-5p	↑↑	(this study)	↑ C2C12 diff [28, 33]
14	miR-30a-3p	↑	(this study)	↑ C2C12 diff [33]
15	miR-30c	↑	↑pMyo diff. [26]	↑ C2C12 diff [33]	↑ muscle development [31]
16	miR-30d	↑↑	(this study)	↑ pMyo diff [33]
17	miR-30e-3p	↑	(this study)	↑ pMyo diff [33]
18	miR-31 (n)	↓	(this study)
19	miR-98 (n)	↑	(this study)
20	miR-99a	↓	(this study)	↑ C2C12 diff [33] ↑ pMyo diff [33]
21	miR-101	↑↑	(this study)	-	↑ muscle development [31]
22	miR-103 (n)	↑	(this study)
23	miR-107 (n)	↑	(this study)	-
24	miR-126	↑↑	(this study)	↓ C2C12 diff [33]
25	miR-128b	↑↑↑	↑ pMyo diff. [27]	↑ C2C12 diff [28] ↑ pMyo diff [33]
26	miR-133a	↑↑↑	enriched in sk. muscle[15]↑pMyo diff. [26] ↑ muscle development [30]	↑ C2C12 diff [8, 10, 33] ↑ pMyo diff [33]	↑ muscle development [31]	↑ muscle development [32]
27	miR-133b	↑↑↑	enriched in sk. muscle[15] ↑ muscle development [30]	↑ C2C12 diff [8, 10] ↑ pMyo diff [33]
28	miR-140	↑	(this study)	↑ pMyo diff [33]
29	miR-152	↑	(this study)	↑ C2C12 diff [28]
30	miR-155	↓↓	(this study)	↓ C2C12 diff [34, 35] ↓ pMyo diff [33]
31	miR-181b	↑	(this study)	↑ C2C12 diff [16, 28, 33] ↑ pMyo diff [33]		enriched in the heart [32]
32	miR-183	↓	(this study)	↓ C2C12 diff [33]
33	miR-192	↑↑	(this study)	↑ pMyo diff [33]
34	miR-193a (n)	↑↑	(this study)	-
35	miR-204	↓↓	↓ pMyo diff. [27]	-
36	miR-206	↑↑	enriched in sk. muscle[15] ↑ muscle development [30]	↑ C2C12 diff [8, 10, 33] ↑ pMyo diff [33]		↑ muscle development
37	miR-210 (n)	↑	(this study)
38	miR-221	↓	↑pMyo diff. [26]↓ pMyo diff. [27]	↓quail myoblasts diff, ↓ C2C12 diff [29]
39	miR-222	↓	↑pMyo diff. [26] ↓ pMyo diff. [27]	↓quail myoblasts diff, ↓ C2C12 diff [29] ↓ C2C12 diff [28]		↓ muscle development [32]
40	miR-320	↓	(this study)	↑ pMyo diff [33]
41	miR-324-3p (n)	↑↑	(this study)
42	miR-324-5p (n)	↑	(this study)
43	miR-331 (n)	↑	(this study)	-
44	miR-339	↓	(this study)	↑ C2C12 diff [33] ↑ pMyo diff [33]
45	miR-361	↑	(this study)	↑ pMyo diff [33]
46	miR-362	↑↑	(this study)	↑ C2C12 diff [28]
47	miR-374 (n)	↑	(this study)
48	miR-432 (n)	↑	(this study)
49	miR-451 (n)	↓↓↓	(this study)
50	miR-452 (n)	↓↓	(this study)
51	miR-500	↑↑	(this study)	↑ C2C12 diff [28, 33] ↑ pMyo diff [33]
52	miR-501	↑↑↑	(this study)	↑ C2C12 diff [28, 33]
53	miR-502 (n)	↑↑	(this study)	-
54	miR-503	↑	(this study)	↑ C2C12 diff [19, 28, 33] ↑ pMyo diff [33]
55	miR-532	↑↑	(this study)	↑ C2C12 diff [28, 33] ↑ pMyo diff [33]
56	miR-550	↓	↓ pMyo diff. [27]	-
57	miR-565 (n)	↓	(this study)	-
58	miR-594 (n)	↓	(this study)
59	miR-659 (n)	↓↓↓	(this study)	-
60	miR-660 (n)	↑↑↑	(this study)	-

In bold are human-specific MR-miRs (hMR-miRs, 16 in total); Italicized are microRNAs shown to be differentially expressed during myogenesis in non- human cells; microRNAs with a known function in myogenesis are underscored. (n): microRNAs that we have shown to be differentially expressed during myogenesis for the first time in our study. The number of arrows corresponds to the level of up- or downregulation of microRNAs. One arrow: fold change 1 to 3 fold, two arrows: fold change 3 to 7 times, three arrows: fold change 7 to infinity.

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ISSN: 1471-2164

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