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Figure 1 | BMC Genomics

Figure 1

From: Origins of amyloid-β

Figure 1

Conserved Regions of the Amyloid-β Precursor Protein Gene Family. Schematic representations of the five members of the Amyloid-β Precursor Protein (AβPP) gene family show multiple conserved domains: N-Terminal Signal peptide (NTS), growth factor-like domain (GFLD), heparin binding domain (Hep), copper binding domain (Cu), zinc binding domain (Zn), an acidic amino-acid rich region (D/E), collagen binding domain (Col), a basolateral sorting signal (BLS), and a clathrin-binding internalization signal domain (YENPTY). Certain members of the gene family also contain a Kunitz-protease inhibitor domain (KPI), the amyloid-β forming region (βA4), an OX-2 domain (diagonal hashmarks), a putative collagen binding domain (horizontal white hashmarks), and/or a glutamine and serine-rich region (Q/S).

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