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Figure 1 | BMC Genomics

Figure 1

From: Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs

Figure 1

A comparison of psychotropic drugs based on pattern of gene expression alterations in the striatum. Cluster dendrogram (A) and PCA plot (B) were generated based on expression profile of top 300 drug-responsive genes. Distance between drugs corresponds to a divergence in the profile of drug-induced transcriptional alterations. Therapeutic classes of drugs are coded by colors presented on the clustering (green for antidepressants, red for psychostimulants, blue for anxiolytics, brown for antipsychotics and light blue for opioids). First and second components of PCA are shown on x and y axis, while third component is coded by color and size of the circles as presented on the right.

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