Figure 2

Drug-induced gene expression networks in the striatum. Gene networks α, β, γ were identified by hierarchical clustering of top drug-regulated transcripts (A). Map of the striatal transcriptome represented as minimal spanning tree (B). Each node represents one transcript. The inter-node distance is proportional to the Spearman correlation of the expression levels of two genes. The node color of drug-responsive transcripts indicates the level of correlation between gene expression and PCA components (see Figure 1b), according to a triangle scale.