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Figure 5 | BMC Genomics

Figure 5

From: Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs

Figure 5

Prediction of tianeptine targets by gene expression profiling. A matrix of drug-target binding interactions from the PDSP Ki database (A). The mechanisms of tianeptine action predicted from expression profiles of the transcripts most sensitive to the analyzed pharmacological mechanisms (B). Brain distribution of tianeptine-induced gene expression alterations of Arc and Egr1 and (C). Rewarding properties of tianeptine in the conditioned place preference test. Scores are expressed as means + standard error of the mean (t-test, **P < 0.01) (D).

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