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Table 2 Major plasma membrane and intracellular transporters of Wallemia ichthyophaga (Wi) and Wallemia sebi (Ws)

From: Genome and transcriptome sequencing of the halophilic fungus Wallemia ichthyophaga: haloadaptations present and absent

Cellular locationa

Transporter type

Substrate specificity/ main function

Name of the Scbhomologue

Number of homologues in Wic

Number of homologues in Wsd

PM

Channel

K+ efflux

Tok1

0

0

Uniporter

K+ uptake

Trk1,2

1

1

P-type ATPase

Na+ (and Li+) efflux

Ena1,2,5

2c

1

Antiporter

Na+, (K+)/ H+ exchange

Nha1

2

2

Antiporter

Na+/H+ exchange

/

1

1

Symporter

Na+/Pi cotransporter

Pho89

1 ↑d

1

P-type ATPase

H+ export

Pma1,2

3

2

unknown

Permease

Ca2+ permease

/

1

1

Antiporter

Ca2+/H+ exchange

/

1

1

P-type ATPase

cation transporting, unknown specificity

/

2 ↓e

2

GA

Antiporter

K+/H+ exchange

Kha1

2

2

P-type ATPase

Ca2+ and Mn2+ transport into GA

Pmr1

1

1

LE

Antiporter

Na+, (K+)/ H+ exchange

Nhx1

1

1

Antiporter

Na+, K+ /H+ exchange

Vnx1

1

1

VAC

V-type ATPase

H+ in vacuole

Vma1

1

1

P-type ATPase

depleting cytosol of Ca2+ ions

Pmc1

1

1

MTH

Antiporter

K+/H+ exchange

Mrs7/Mdm38

1

1

  1. aPM plasma membrane, GA Golgi apparatus, LE late endosomes, VAC vacuole, MTH mitochondria.
  2. bSc, S. cerevisiae; bold numbers mark differences in numbers of transporters between W. ichthyophaga and W. sebi.
  3. c,d,e Differential expression of the transporter homologues in W. ichthyophaga (log2 ratios: c: ↓ -1.00; d: ↑ +1.52; e: ↓ -1.27).