Class | Gene | Description | Functions | Ref |
---|---|---|---|---|
IL1 NODE | IL1 | Pro-inflammatory cytokine involved in host defense | Activation of NF-kappaB; Induction of acute and chronic inflammation | [20] |
IL1B | Cytokine activated by Caspase 1 | Cell proliferation; Cell differentiation; Apoptosis | [21] | |
IL1R1 | Cytokine receptor 1 | Immune and inflammatory response | [20] | |
S100A13 | Calcium binding protein induced by inflammatory stress | Cell cycle progression; Cellular differentiation | [22] | |
TWIST2 | MSCs marker | Negative regulator of IL1B; Cell lineage determination; Cellular differentiation | ||
AKT NODE | AKT | Protein kinase B | Cellular growth; Mitosis; Cellular differentiation | [25] |
RAC2 | Member of Rho GTPase family | Proliferation; Cellular differentiation; Cytoskeletal organization; Cellular adhesion; Membrane trafficking, Transcriptional regulation | ||
PTPRF | LAR protein tyrosine phosphatase sigma family | Neuronal differentiation; Cellular development | [28] | |
Transcription regulators | CREBBP | CREB binding protein | Histone acetyltransferase activity; Transcriptional regulation | [29] |
PARP1 | Poly (ADP-ribose) polymerase | Cellular proliferation; Cellular differentiation | [30] | |
HNRNPAB | Ribonucleoprotein associated with pre-mRNAs | RNA processing and trafficking; Cellular differentiation | [31] | |
NONO | RNA-binding protein | Transcriptional regulation; RNA splicing; RNA retention in nucleus | [32] | |
Cytoskeleton organization | ACTR3 | Actin-related protein | Neuronal differentiation | [33] |
NISCH | Nischarin | Negative role in cell migration | [34] | |
Neural markers | EPHA4 | Ephrin recepotor of protein-tyrosine kinase family | Nervous system development | [35] |
MT2A | Melatonin recepror 2 | Expressed in neural progenitor | [36] | |
CDH2 | Cadherin | Cellular differentiation via RAC | [37] | |
ERRFI1 | Cytoplasmic protein | Induced by cellular stress; Cell signalling | [38] | |
RNF7 | Ring finger protein | Part of protein degradation machinery; Antiapoptotic activity via JUN | [39] | |
LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene | Tyrosine kinase activity; Cellular proliferation | [40] |