Class | Gene | Description | Functions | Ref |
---|---|---|---|---|
TP53 NODE | TP53 | Major tumor protein suppressor | Cell cycle; Apoptosis; Senescence | |
UBE2D3 | Member of E2 ubiquitin conjugating enzyme family | Protein degradation machinery | [43] | |
MAP2K3 | Protein kinase activated by environmental stress | Gene expression regulation; Mitosis; Cellular differentiation; Cellular proliferation; Apoptosis; Senescence | [44] | |
ZHX1 | Zing finger and homeoboxes gene family | Maintenance of TP53 gene silencing | [45] | |
XPO1 | Exportin 1 | Protein trafficking; Localization of cyclin b; Localization of MPAK; Nuclear export of TP53 | [46] | |
PIN1 | Phosphorylation-dependent prolyne isomerase | Cellular differentiation; Cellular proliferation; Immune response; Mitosis | ||
CDC27 | Component of anaphase promoting complex | Mitosis; Ubiquitination | [49] | |
ANAPC2 | Anaphase promoting complex | Cell cycle control; Ubiquitination | [50] | |
Cell cycle regulation and differentiation | TYMS | Thymidylate syntase | DNA replication and repair; Mitosis | [51] |
FGFR3 | Fibroblast growth factor receptor 3 | Mitosis; MSCs differentiation | ||
NCAPD2 | Subunit of condensin I | Mitosis; Proliferation | ||
MITF | Transcription factor | Cell cycle regulation; Gene expression; Differentiation | ||
Oxidative stress response | RPS3 | Ribosomal protein (40s subunit) | DNA damage repair; Kinase activity on NFkB complex | [59] |
NFE2L2 | Human basic leucine zipper transcription factor | Oxidative stress response | [60] | |
HSP1 | Heat-shock protein 1 | Protein folding | ||
NFkB signalling | IKBKG | Regulatory subunit of IKK complex | NFkB activation | [64] |
MYL5 | Myosin light chain | NFkB activation | ||
Apoptosis | SLC6A4 | Membrane serotonin transporter | Apoptosis | [67] |
Histonic modification | HAT1 | Histone acetyltransferase B | Histone acetylation; Aging; Cellular differentiation | [68] |
HIST1H3C | Member of Histone H3 family | Transcriptional regulation; Cellular differentiation | [69] |