Figure 2

Pathway analysis of hepatic genes differentially regulated by 17β-trenbolone: Impacts on metabolic pathways. Connections between significantly up or down-regulated genes in the liver and enriched Biological Processes from human homolog data were visualized. The red color represents up-regulation by TB and blue color represents down-regulation by TB compared to the samples exposed to the vehicle control. The intensity of the color is correlated with the degree of differential regulation. Red solid lines represent positive regulation of gene expression, blue solid lines represent negative regulation of gene expression, and grey solid lines represent unknown direction of regulation. Oval shapes represent individual genes and boxes represent GO Biological Processes. Gene abbreviations: COX2: cyclooxygenase II; CYBA: cytochrome b-245, alpha polypeptide; CYBB: cytochrome b-245, beta polypeptide; CYB5A: cytochrome b5 type A (microsomal); CYC1: cytochrome c-1;CYCS: cytochrome c, somatic; CYGB: cytoglobin; CYP(number)(letter)(number) for all entries: cytochrome P450, family number, subfamily letter, polypeptide variant number; DOCK2: dedicator of cytokinesis 2; EPX: eosinophil peroxidase; GUCY1B3: guanylate cyclase 1, soluble, beta 3;MB: myoglobin; MPO: myeloperoxidase; NOS1: nitric oxide synthase 1; NOX5: NADPH oxidase, EF-hand calcium binding domain 5; PRDX1: peroxiredoxin 1; SDHC: succinate dehydrogenase complex, subunit C, integral membrane protein, 15 kDa; TDO2: tryptophan 2,3-dioxygenase.