Figure 6

Tpk2 binding specificity. A. Consensus sequences for Tpk2 binding sites in yeast cells (left) or in cells induced for hypha formation (right). The program RSAT dyad-analysis [36] was used to predict consensus sequences. Predicted dyads (pairs of trinucleotides) common to Tpk2 binding sites were ranked and qualified by their P-/E-values; the frequencies of the deduced consensus sequences and of closely related sequences relative to all binding sites are listed below each table. B. Occurrence of trinucleotides/codons in ORF regions bound by Tpk2 during yeast growth. Codons corresponding to the Tpk2 binding consensus sequence are listed, along with codon frequencies in all C. albicans ORFs, in a randomly picked group of 150 genes not binding Tpk2 (out group) and in the 204 Tpk2 binding regions occurring mostly within ORFs.