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Figure 1 | BMC Genomics

Figure 1

From: Accurate detection of subclonal single nucleotide variants in whole genome amplified and pooled cancer samples using HaloPlex target enrichment

Figure 1

Allele fractions for putative single nucleotide variants (SNVs) in ALL and normal samples. The allele fractions observed in HaloPlex sequence data for 1509 candidate SNVs in ALL and normal samples. Only data from libraries derived from genomic DNA are shown. SNVs classified as somatic are shown in red. Candidate SNVs that follow the x = y line represent putative germline SNPs that escaped detection in the normal sample during WGS or alignment artifacts. The cluster with allele fractions close to 0 in both ALL and normal samples represents likely false positive SNV calls. Most of the candidate SNVs with allele fractions close to 1 in the ALL sample and around 0.5 in the normal sample in patient 2 are located in a large region of somatic loss of heterozygosity.

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