Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles

Table 3 Replication of candidate genes in the Demirkan et al. dataset

Gene	Trait	SNP from the Illig et al. dataset	p-value¹	SNP from the Demirkan et al. dataset	p-value²	Combined p-value³
ADCY8	PC ae C40:6	rs11786743	4.03E-05	rs913819	6.73E-04	2.15E-07
CBS ^*	PC ae C40:6	rs2839631	5.67E-06	rs378376	5.17E-04	2.90E-08
CNR1	PC ae C38:2	rs10485168	2.42E-04	rs9359765	4.61E-04	7.54E-07
GPAM ^*	PC ae C34:3	rs2246253	1.25E-04	rs2419603	1.76E-04	1.56E-07
HSD17B12	PC aa C34:4	rs2862999	2.66E-05	rs11037685	6.13E-04	1.35E-07
MBOAT1	PC ae C40:6	rs9465673	1.11E-04	rs694094	4.47E-04	3.53E-07
PECR	PC aa C38:0	rs3770536	5.55E-04	rs3770562	9.43E-05	3.79E-07
PLCB1	PC aa C30:0	rs6056188	9.55E-06	rs17363114	1.96E-03	2.06E-07
TECR	PC aa C32:0	rs7252966	1.69E-05	rs7254215	2.09E-03	3.57E-07

Top hits from the meta-analysis of candidate genes identified in the Illig et al. study and replicated in the Demirkan et al. dataset. ^1,2,3p-value of association of the SNP with the trait in the Illig et al., Demirkan et al. and combined p-value respectively. ^*indicates genes for which further evidence was found.

ISSN: 1471-2164