Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: comparative genomics reconstruction of metabolic and regulatory networks

Table 2 Reconstructed regulons for utilization of monosaccharides in B. thetaiotaomicron

Regulator name¹	Locus tag²	Regulator orthologs³	Sugar utilization pathways controlled by regulon	Regulator family	References
AraR^*	BT0354	8	Arabinose, arabinan	NrtR
Crp	BT4338	11	Multiple sugars	Crp
FucR	BT1272	7	Fucose	GntR	[41]
KdgR^*	BT0487	10	Glucuronate, galacturonate	LacI
ManR^*	BT2103	3	Mannose, mannosides	GntR
NanR^*	BT0433	11	Sialic acid; N-acetylglucosamine	ROK
RhaR	BT3768	8	Rhamnose	AraC	[39, 40]
UxaR^*	BT0824	6	Glucuronate, galacturonate	LacI
UxmR^*	BT3613	6	Mannuronate	LacI
UxuR^*	BT1434	3	Glucuronate	LacI
XylR^*	BT0791	10	Xylose	NrtR

¹Novel regulators identified in this research are marked by asterisks. ²Regulator locus tags are shown for B. thetaiotaomicron VPI-5482. ³Number of regulator’s orthologs found in 11 analyzed genomes of Bacteroides spp.

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