Figure 4

Upstream regulators and their target molecules in datasets as identified by Ingenuity Pathway Analysis (IPA). A – The list of differentially regulated on microarray (n = 418) and Ensembl reannotated genes was used as an input for analysis; B – Subset of these genes (n = 28; List eQG from [18]) was used as an input. Molecules in red denote up-regulation, molecules in green denote down-regulation and molecules in orange denote predicted activation in response to 6 hours infection with live Staphylococcus aureus in bovine macrophages. Lines in orange denote predicted activation; lines in blue - predicted inhibition; lines in yellow - findings inconsistent with state of downstream molecule; and lines in grey - effect not predicted.